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dc.creatorMessinis, I. E.en
dc.creatorMilingos, S. D.en
dc.date.accessioned2015-11-23T10:39:27Z
dc.date.available2015-11-23T10:39:27Z
dc.date.issued1997
dc.identifier10.1093/humupd/3.3.235
dc.identifier.issn1355-4786
dc.identifier.urihttp://hdl.handle.net/11615/30941
dc.description.abstractGreat progress has been achieved during the last 20 years in the field of ovulation induction in patients with polycystic ovary syndrome (PCOS). Clomiphene citrate remains the first line of treatment for all anovulatory women with PCOS, since in properly selected patients the cumulative pregnancy rate approaches that in normal women, Human urinary gonadotrophins have been used extensively for ovulation induction, but the development of low-dose regimens has opened a new era in the management of anovulation related to PCOS, This article discusses the main advantages and disadvantages of the principal methods and regimens currently used for ovulation induction in patients with PCOS including clomiphene citrate, gonadotrophins, pulsatile gonadotrophin-releasing hormone (GnRH) and GnRB agonists, It also discusses new drugs discovered recently, particularly recombinant gonadotrophins and GnRH antagonists, and provides some thoughts regarding their use in future protocols, Finally, based on the discovery of new ovarian substances which specifically control luteinizing hormone (LH) secretion, this article develops assumptions on possible implications of these substances in the pathophysiology of PCOS and their potential use in the management of the syndrome.en
dc.source.uri<Go to ISI>://WOS:A1997XY07900005
dc.subjectclomiphene citrateen
dc.subjectgonadotrophinsen
dc.subjectovulation inductionen
dc.subjectpolycysticen
dc.subjectovary syndromeen
dc.subjectFOLLICLE-STIMULATING-HORMONEen
dc.subjectGONADOTROPIN-RELEASING-HORMONEen
dc.subjectHUMANen
dc.subjectMENOPAUSAL GONADOTROPINen
dc.subjectHUMAN CHORIONIC-GONADOTROPINen
dc.subjectIN-VITROen
dc.subjectFERTILIZATIONen
dc.subjectSURGE-ATTENUATING FACTORen
dc.subjectHUMAN MENSTRUAL-CYCLEen
dc.subjectCLOMIPHENE CITRATE THERAPYen
dc.subjectHUMAN LUTEINIZING-HORMONEen
dc.subjectEXOGENOUSen
dc.subjectGONADOTROPINSen
dc.subjectObstetrics & Gynecologyen
dc.subjectReproductive Biologyen
dc.titleCurrent and future status of ovulation induction in polycystic ovary syndromeen
dc.typejournalArticleen


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