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Regulation of aromatase expression by hormones, drugs pesticides and environmental pollutants in canine mammary CMT-U27 cells

dc.creatorMavridis, S. K.en
dc.creatorPappas, I. S.en
dc.date.accessioned2015-11-23T10:39:06Z
dc.date.available2015-11-23T10:39:06Z
dc.date.issued2010
dc.identifier.issn10116583
dc.identifier.urihttp://hdl.handle.net/11615/30798
dc.description.abstractAromatase, the enzyme that coverts testosterone to 17β-estradiol, has attracted attention lately because of its involvement in some forms of breast cancer in women. Studies are now undergoing on a variety of species to elucidate the effect of various agents on aromatase expression. Dog is an important species, widely used by the pharmaceutical industry for many study types, including those that will impact decision on drug development. In the present study, a wide variety of agents, including steroid hormones, drugs, pesticides, and environmental pollutants, were used to investigate their effect on aromatase expression in the canine mammary CMT-U27 cell line using quantitative real-time polymerase chain reaction (qPCR) on DNA synthesized from RNA extracted from the cells. ©PHARMAKON-Press.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-77954400101&partnerID=40&md5=604ca7c85b5b497ff5b79f389a3dadd9
dc.subjectAromataseen
dc.subjectBreast canceren
dc.subjectInducersen
dc.subjectInhibitorsen
dc.subjectRegulationen
dc.subject4,4' isopropylidenediphenolen
dc.subjectatrazineen
dc.subjectbutyric aciden
dc.subjectcolecalciferolen
dc.subjectcorticosteroneen
dc.subjectcurcuminen
dc.subjectdexamethasoneen
dc.subjectdichloroacetic aciden
dc.subjectDNAen
dc.subjectestradiolen
dc.subjectforskolinen
dc.subjectgenisteinen
dc.subjectliothyronineen
dc.subjectmetforminen
dc.subjectn [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamideen
dc.subjectpesticideen
dc.subjectprochlorazen
dc.subjectprogesteroneen
dc.subjectquercetinen
dc.subjectrapamycinen
dc.subjectretinoic aciden
dc.subjectrhapontinen
dc.subjectRNAen
dc.subjectrofecoxiben
dc.subjectroscovitineen
dc.subjectrosiglitazoneen
dc.subjectsteroid hormoneen
dc.subjecttestosteroneen
dc.subjectanimal cellen
dc.subjectbreast cellen
dc.subjectcell lineen
dc.subjectcmt u27 cell lineen
dc.subjectconference paperen
dc.subjectDNA synthesisen
dc.subjectdogen
dc.subjectenzyme activityen
dc.subjectenzyme inhibitionen
dc.subjectenzyme regulationen
dc.subjectgene expression regulationen
dc.subjectgene inductionen
dc.subjectgene repressionen
dc.subjectnonhumanen
dc.subjectpollutanten
dc.subjectprotein expressionen
dc.subjectquantitative analysisen
dc.subjectreal time polymerase chain reactionen
dc.subjectRNA extractionen
dc.titleRegulation of aromatase expression by hormones, drugs pesticides and environmental pollutants in canine mammary CMT-U27 cellsen
dc.typejournalArticleen


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