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Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates

dc.creatorMarcoulatos, P.en
dc.creatorKoussidis, G.en
dc.creatorMamuris, Z.en
dc.creatorVelissariou, V.en
dc.creatorVamvakopoulos, N. C.en
dc.date.accessioned2015-11-23T10:38:51Z
dc.date.available2015-11-23T10:38:51Z
dc.date.issued1996
dc.identifier.issn10799907
dc.identifier.urihttp://hdl.handle.net/11615/30692
dc.description.abstractInterleukin-2 (IL-2) is the first lymphokine secreted following T cell activation. Several transcription factors regulate IL-2 gene expression, including the nuclear factor of activated T cells (NFAT). NFAT acts at the antigen receptor response element-2 (ARRE-2) sequence in the IL-2 enhancer and is the nuclear target of T cell stimulation signals and the immunosuppressant drugs cyclosporine and FK506, which are potent inhibitors of IL-2 gene transcription. NFAT has been cloned and found to consist of two subunits, NF45 (ILF2) and NF90 (ILF3). This communication reports the assignment of NF45, interleukin enhancer binding factor 2 gene (ILF2), to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction (PCR) amplification of ILF2-specific DNA sequences from well-characterized human-rodent somatic cell hybrid DNA.en
dc.sourceJournal of Interferon and Cytokine Researchen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-0030478813&partnerID=40&md5=2d388c2a33224d0b1c38142cd7235f32
dc.subjectinterleukin 2en
dc.subjectanimal cellen
dc.subjectarticleen
dc.subjectchromosome 1pen
dc.subjectchromosome 1qen
dc.subjectchromosome mapen
dc.subjectdna sequenceen
dc.subjectdna templateen
dc.subjectgene amplificationen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjecthybrid cellen
dc.subjectnonhumanen
dc.subjectpolymerase chain reactionen
dc.subjectpriority journalen
dc.subjectt lymphocyte activationen
dc.subjectAnimalsen
dc.subjectChromosome Mappingen
dc.subjectChromosomes, Human, Pair 1en
dc.subjectDNAen
dc.subjectDNA-Binding Proteinsen
dc.subjectHumansen
dc.subjectHybrid Cellsen
dc.subjectMolecular Sequence Dataen
dc.subjectNFATC Transcription Factorsen
dc.subjectNuclear Factor 45 Proteinen
dc.subjectNuclear Factor 90 Proteinsen
dc.subjectNuclear Proteinsen
dc.subjectRodentiaen
dc.subjectTemplates, Geneticen
dc.subjectTranscription Factorsen
dc.subjectAnimaliaen
dc.titleMapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templatesen
dc.typejournalArticleen


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