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dc.creatorMantzana, P.en
dc.creatorPournaras, S.en
dc.creatorSkentou, C.en
dc.creatorDeligeoroglou, E.en
dc.creatorKatsioulis, A.en
dc.creatorAntonakopoulos, G.en
dc.creatorHadjichristodoulou, C.en
dc.creatorTsakris, A.en
dc.creatorMessinis, I. E.en
dc.creatorDaponte, A.en
dc.date.accessioned2015-11-23T10:38:49Z
dc.date.available2015-11-23T10:38:49Z
dc.date.issued2014
dc.identifier10.2217/fvl.14.11
dc.identifier.issn1746-0794
dc.identifier.urihttp://hdl.handle.net/11615/30678
dc.description.abstractAim:To conduct a pilot cross-sectional study to evaluate the rates of detection of four common high-risk HPV (hr-HPV) types using first-void urine paired with vaginal self-obtained samples in a nonvaccinated population of pregnant women. We also aimed to compare these results with a matched nonpregnant group in order to test the applicability of self-sampled hr-HPV cervical cancer screening during antenatal visits. Materials & methods: Samples from 550 pregnant women were subjected to hr-HPV-16, -18, -31 and -45 type detection by inhouse PCR and compared with 250 paired urine, vaginal and cervical samples from an age-matched cohort of nonpregnant women. Results: Comparing overall hr-HPV prevalence in urine and vaginal samples between pregnant (15 out of 550; 2.7%) and nonpregnant women (eight out of 250; 3.2%) for each HPV type revealed no significant differences. All paired urine/vaginal samples were both positive for the same type of hr-HPV and there was no positive urine sample with the other samples being negative. Conclusion: hr-HPV detection in pregnant women using self-obtained urine and vaginal samples seems to be a feasible cervical cancer screening method.en
dc.sourceFuture Virologyen
dc.source.uri<Go to ISI>://WOS:000335564900010
dc.subjectHPV-16en
dc.subjectHPV-18en
dc.subjectHPV-31en
dc.subjectHPV-45en
dc.subjectHPV pregnancyen
dc.subjectHPV urineen
dc.subjectHPV vaginaen
dc.subjectscreeningen
dc.subjectself-samplingen
dc.subjectHUMAN-PAPILLOMAVIRUS DNAen
dc.subjectRISK HUMAN-PAPILLOMAVIRUSen
dc.subjectOF-THE-LITERATUREen
dc.subjectREAL-TIME PCRen
dc.subjectCOLLECTED SAMPLESen
dc.subjectCHLAMYDIA-TRACHOMATISen
dc.subjectINTRAEPITHELIALen
dc.subjectNEOPLASIAen
dc.subjectCERVICOVAGINAL LAVAGEen
dc.subjectGENOTYPE DISTRIBUTIONen
dc.subjectNONPREGNANTen
dc.subjectWOMENen
dc.subjectVirologyen
dc.titleApplicability of self-obtained urine and vaginal samples for HPV-16,-18,-31 and-45 cervical cancer screening in pregnancy: a pilot cross-sectional studyen
dc.typejournalArticleen


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