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dc.creatorLiu, C. T.en
dc.creatorEstrada, K.en
dc.creatorYerges-Armstrong, L. M.en
dc.creatorAmin, N.en
dc.creatorEvangelou, E.en
dc.creatorLi, G.en
dc.creatorMinster, R. L.en
dc.creatorCarless, M. A.en
dc.creatorKammerer, C. M.en
dc.creatorOei, L.en
dc.creatorZhou, Y. H.en
dc.creatorAlonso, N.en
dc.creatorDailiana, Z.en
dc.creatorEriksson, J.en
dc.creatorGarcia-Giralt, N.en
dc.creatorGiroux, S.en
dc.creatorHusted, L. B.en
dc.creatorKhusainova, R. I.en
dc.creatorKoromila, T.en
dc.creatorKung, A. W.en
dc.creatorLewis, J. R.en
dc.creatorMasi, L.en
dc.creatorMencej-Bedrac, S.en
dc.creatorNogues, X.en
dc.creatorPatel, M. S.en
dc.creatorPrezelj, J.en
dc.creatorRichards, J. B.en
dc.creatorSham, P. C.en
dc.creatorSpector, T.en
dc.creatorVandenput, L.en
dc.creatorXiao, S. M.en
dc.creatorZheng, H. F.en
dc.creatorZhu, K.en
dc.creatorBalcells, S.en
dc.creatorBrandi, M. L.en
dc.creatorFrost, M.en
dc.creatorGoltzman, D.en
dc.creatorGonzalez-Macias, J.en
dc.creatorKarlsson, M.en
dc.creatorKhusnutdinova, E. K.en
dc.creatorKollia, P.en
dc.creatorLangdahl, B. L.en
dc.creatorLjunggren, O.en
dc.creatorLorentzon, M.en
dc.creatorMarc, J.en
dc.creatorMellstroem, D.en
dc.creatorOhlsson, C.en
dc.creatorOlmos, J. M.en
dc.creatorRalston, S. H.en
dc.creatorRiancho, J. A.en
dc.creatorRousseau, F.en
dc.creatorUrreizti, R.en
dc.creatorVan Hul, W.en
dc.creatorZarrabeitia, M. T.en
dc.creatorCastano-Betancourt, M.en
dc.creatorDemissie, S.en
dc.creatorGrundberg, E.en
dc.creatorHerrera, L.en
dc.creatorKwan, T.en
dc.creatorMedina-Gomez, C.en
dc.creatorPastinen, T.en
dc.creatorSigurdsson, G.en
dc.creatorThorleifsson, G.en
dc.creatorVanMeurs, J. B. J.en
dc.creatorBlangero, J.en
dc.creatorHofman, A.en
dc.creatorLiu, Y. M.en
dc.creatorMitchell, B. D.en
dc.creatorO'Connell, J. R.en
dc.creatorOostra, B. A.en
dc.creatorRotter, J. I.en
dc.creatorStefansson, K.en
dc.creatorStreeten, E. A.en
dc.creatorStyrkarsdottir, U.en
dc.creatorThorsteinsdottir, U.en
dc.creatorTylavsky, F. A.en
dc.creatorUitterlinden, A.en
dc.creatorCauley, J. A.en
dc.creatorHarris, T. B.en
dc.creatorIoannidis, J. P. A.en
dc.creatorPsaty, B. M.en
dc.creatorRobbins, J. A.en
dc.creatorZillikens, M. C.en
dc.creatorVanDuijn, C. M.en
dc.creatorPrince, R. L.en
dc.creatorKarasik, D.en
dc.creatorRivadeneira, F.en
dc.creatorKiel, D. P.en
dc.creatorCupples, L. A.en
dc.creatorHsu, Y. H.en
dc.description.abstractSexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS) and femoral neck (FN) BMD in 25,353 individuals from 8 cohorts. In a second stage, we followed up the 12 top single-nucleotide polymorphisms (SNPs; p?<?1?X?10-5) in an additional set of 24,763 individuals. Gene-by-sex interaction and sex-specific effects were examined in these 12 SNPs. We detected one novel genome-wide significant interaction associated with LS-BMD at the Chr3p26.1-p25.1 locus, near the GRM7 gene (male effect?=?0.02 and p?=?3.0?X?10-5; female effect?=?-0.007 and p?=?3.3?X?10-2), and 11 suggestive loci associated with either FN- or LS-BMD in discovery cohorts. However, there was no evidence for genome-wide significant (p?<?5?X?10-8) gene-by-sex interaction in the joint analysis of discovery and replication cohorts. Despite the large collaborative effort, no genome-wide significant evidence for gene-by-sex interaction was found to influence BMD variation in this screen of autosomal markers. If they exist, gene-by-sex interactions for BMD probably have weak effects, accounting for less than 0.08% of the variation in these traits per implicated SNP. (c) 2012 American Society for Bone and Mineral Research.en
dc.source.uri<Go to ISI>://WOS:000308925800003
dc.subjectEndocrinology & Metabolismen
dc.titleAssessment of gene-by-sex interaction effect on bone mineral densityen

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