Crohn's disease-specific pancreatic autoantibodies are specifically present in ruminants with paratuberculosis: Implications for the pathogenesis of the human disease

Liaskos, C.; Spyrou, V.; Roggenbuck, D.; Athanasiou, L. V.; Orfanidou, T.; Mavropoulos, A.; Reinhold, D.; Rigopoulou, E. I.; Amiridis, G. S.; Billinis, C.; Bogdanos, D. P.

Resumen

Mycobacterium avium subspecies paratuberculosis (MAP) induces paratuberculosis (ptb) in ruminants and has clinical and histological features resebling Crohn's disease (CD). Pancreatic autoantibodies (PAB) targeting glycoprotein 2 (GP2) are specifically found in CD, but it is currently unknown whether these autoantibodies can be found in ruminants with ptb. IgG anti-MAP and anti-GP2 antibodies were tested by ELISA in 286 ruminants (212 sheep and 74 cattle). PAB testing was performed by indirect immunofluorescence (IF) using anti-sheep or anti-cattle specific antisera. PCR analysis confirmed the presence of MAP in anti-MAP positive samples. Anti-GP2 antibodies were more prevalent in anti-MAP antibody positive (26.9%) than in anti-MAP negative ruminants (8.7%, p<0.001). Anti-GP2 antibodies were found in 16/70 (22.9%) anti-MAP positive sheep compared to 10/142 (7%, p=0.001) anti-MAP antibody negative and in anti-MAP positive cattle than in negative counterparts (5/8 versus 8/66, p=0.003). Absorbance values for anti-GP2 antibodies were higher in cattle than in sheep (mean 21 AU/mL +/- 25.45D versus 12.2 AU/mL +/- 23 SD, p<0.001). There was no correlation between anti-GP2 and anti-MAP antibody concentrations. Anti-GP2 antibodies persisted up to 1/1000 and showed the characteristic IIF pancreatic pattern seen by anti-GP2 antibody positive CD samples. This is the first study to demonstrate the presence of CD-specific GP2-reactive pancreatic autoantibodies in MAP-infected ruminants. Our data suggest that CD and ptb are characterised by an antigen-driven loss of immunological tolerance to GP2, implying commonalities in the immunopathogenesis of the human and ruminant inflammatory bowel disorder.

URI

http://hdl.handle.net/11615/30338

Colecciones

Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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Manyazewal T., Mapoma C.C., Marczak L.B., Markos D., Martinez-Raga J., Martins-Melo F.R., Martopullo I., McAlinden C., McGaughey M., McGrath J.J., Mehata S., Meier T., Meles K.G., Memiah P., Memish Z.A., Mengesha M.M., Mengistu D.T., Menota B.G., Mensah G.A., Meretoja A., Meretoja T.J., Millear A., Miller T.R., Minnig S., Mirarefn M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mohammad K.A., Mohammadi A., Mohammed S., Mokdad A.H., Mola G.L.D., Mollenkopf S.K., Molokhia M., Monasta L., Hernandez J.C.M., Montico M., Mooney M.D., Moradi-Lakeh M., Moraga P., Morawska L., Morrison S.D., Morozof C., Mountjoy-Venning C., Mruts K.B., Muller K., Murthy G.V.S., Musa K.I., Nachega J.B., Naheed A., Naldi L., Nangia V., Nascimento B.R., Nasher J.T., Natarajan G., Negoi I., Ngunjiri J.W., Nguyen C.T., Nguyen G., Nguyen M., Nguyen Q.L., Nguyen T.H., Nichols E., Ningrum D.N.A., Nong V.M., Noubiap J.J.N., Ogbo F.A., Oh I.-H., Okoro A., Olagunju A.T., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Opio J.N., Oren E., Ortiz A., Osman M., Ota E., Mahesh P.A., Pacella R.E., Pakhale S., Pana A., Panda B.K., Jonas S., Papachristou C., Park E.-K., Patten S.B., Patton G.C., Paudel D., Paulson K., Pereira D.M., Perez-Ruiz F., Perico N., Pervaiz A., Petzold M., Phillips M.R., Pigott D.M., Pinho C., Plass D., Pletcher M.A., Polinder S., Postma M.J., Pourmalek F., Purcell C., Qorbani M., Radfar A., Rafay A., Rahimi-Movaghar V., Rahman M., Ur Rahman M.H., Rai R.K., Ranabhat C.L., Rankin Z., Rao P.C., Rath G.K., Rawaf S., Ray S.E., Rehm J., Reiner R.C., Reitsma M.B., Remuzzi G., Rezaei S., Rezai M.S., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Ruhago G.M., Rizwan S.A., Saadat S., Sachdev P.S., Sadat N., Safdarian M., Saf S., Safiri S., Sagar R., Sahathevan R., Salama J., Salamati P., Salomon J.A., Samy A.M., Sanabria J.R., Sanchez-Niño M.D., Santomauro D., Santos I.S., Milicevic M.M.S., Sartorius B., Satpathy M., Shahraz S., Schmidt M.I., Schneider I.J.C., 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Background: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive ...
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Davletov K., De Leo D., Del Gobbo L.C., Del Pozo-Cruz B., Dellavalle R.P., Deribe K., Deribew A., Des Jarlais D.C., Dey S., Dharmaratne S.D., Dicker D., Ding E.L., Dokova K., Dorsey E.R., Doyle K.E., Dubey M., Ehrenkranz R., Ellingsen C.L., Elyazar I., Enayati A., Ermakov S.P., Eshrati B., Esteghamati A., Estep K., Fürst T., Faghmous I.D.A., Fanuel F.B.B., Faraon E.J.A., Farid T.A., Farinha C.S.E.S., Faro A., Farvid M.S., Farzadfar F., Feigin V.L., Feigl A.B., Fereshtehnejad S.-M., Fernandes J.G., Fernandes J.C., Feyissa T.R., Fischer F., Fitzmaurice C., Fleming T.D., Foigt N., Foreman K.J., Forouzanfar M.H., Franklin R.C., Frostad J., Ghiwot T.T., Gakidou E., Gambashidze K., Gamkrelidze A., Gao W., Garcia-Basteiro A.L., Gebre T., Gebremedhin A.T., Gebremichael M.W., Gebru A.A., Gelaye A.A., Geleijnse J.M., Genova-Maleras R., Gibney K.B., Giref A.Z., Gishu M.D., Giussani G., Godwin W.W., Gold A., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Goto A., Graetz N., Greaves F., Griswold M., Guban P.I., Gugnani H.C., Gupta P.C., Gupta R., Gupta R., Gupta T., Gupta V., Habtewold T.D., Hafezi-Nejad N., Haile D., Hailu A.D., Hailu G.B., Hakuzimana A., Hamadeh R.R., Hambisa M.T., Hamidi S., Hammami M., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Haro J.M., Hassanvand M.S., Havmoeller R., Hay R.J., Hay S.I., Hendrie D., Heredia-Pi I.B., Hoek H.W., Horino M., Horita N., Hosgood H.D., Htet A.S., Hu G., Huang H., Huang J.J., Huntley B.M., Huynh C., Iburg K.M., Ileanu B.V., Innos K., Irenso A.A., Jahanmehr N., Jakovljevic M.B., James P., James S.L., Javanbakht M., Jayaraman S.P., Jayatilleke A.U., Jeemon P., Jha V., John D., Johnson C., Johnson S.C., Jonas J.B., Juel K., Kabir Z., Kalkonde Y., Kamal R., Kan H., Karch A., Karema C.K., Karimi S.M., Kasaeian A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kazanjan K., Keiyoro P.N., Kemmer L., Kemp A.H., Kengne A.P., Kerbo A.A., Kereselidze M., Kesavachandran C.N., Khader Y.S., Khalil I., Khan A.R., Khan E.A., Khan G., Khang Y.-H., Khoja A.T.A., Khonelidze I., Khubchandani J., Kibret G.D., Kim D., Kim P., Kim Y.J., Kimokoti R.W., Kinfu Y., Kissoon N., Kivipelto M., Kokubo Y., Kolk A., Kolte D., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krishnaswami S., Krohn K.J., Kuate Defo B., Kucuk Bicer B., Kuipers E.J., Kulkarni V.S., Kumar G.A., Kumsa F.A., Kutz M., Kyu H.H., Lager A.C.J., Lal A., Lal D.K., Lalloo R., Lallukka T., Lan Q., Langan S.M., Lansingh V.C., Larson H.J., Larsson A., Laryea D.O., Latif A.A., Lawrynowicz A.E.B., Leasher J.L., Leigh J., Leinsalu M., Leshargie C.T., Leung J., Leung R., Levi M., Liang X., Lim S.S., Lind M., Linn S., Lipshultz S.E., Liu P., Liu Y., Lo L.-T., Logroscino G., Lopez A.D., Lorch S.A., Lotufo P.A., Lozano R., Lunevicius R., Lyons R.A., Macarayan E.R.K., Mackay M.T., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahdavi M., Majeed A., Malekzadeh R., Malta D.C., Mantovani L.G., Manyazewal T., Mapoma C.C., Marcenes W., Marks G.B., Marquez N., Martinez-Raga J., Marzan M.B., Massano J., Mathur M.R., Maulik P.K., Mazidi M., McAlinden C., McGrath J.J., McNellan C., Meaney P.A., Mehari A., Mehndiratta M.M., Meier T., Mekonnen A.B., Meles K.G., Memish Z.A., Mengesha M.M., Mengiste D.T., Mengistie M.A., Menota B.G., Mensah G.A., Mereta S.T., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Mills E.J., Minnig S., Mirarefin M., Mirrakhimov E.M., Mock C.N., Mohammad K.A., Mohammed S., Mohanty S.K., Mokdad A.H., Mola G.L.D., Molokhia M., Monasta L., Montico M., Moradi-Lakeh M., Moraga P., Morawska L., Mori R., Moses M., Mueller U.O., Murthy S., Musa K.I., Nachega J.B., Nagata C., Nagel G., Naghavi M., Naheed A., Naldi L., Nangia V., Nascimento B.R., Negoi I., Neupane S.P., Newton C.R., Ng M., Ngalesoni F.N., Ngunjiri J.W., Nguyen G., Ningrum D.N.A., Nolte S., Nomura M., Norheim O.F., Norrving B., Noubiap J.J.N., Obermeyer C.M., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olivares P.R., Olsen H.E., Olusanya B.O., Olusanya J.O., Opio J.N., Oren E., Ortiz A., Osborne R.H., Osman M., Owolabi M.O., Mahesh P.A., Pain A.W., Pakhale S., Palomares Castillo E., Pana A., Papachristou C., Parsaeian M., Patel T., Patton G.C., Paudel D., Paul V.K., Pearce N., Pereira D.M., Perez-Padilla R., Perez-Ruiz F., Perico N., Pesudovs K., Petzold M., Phillips M.R., Pigott D.M., Pillay J.D., Pinho C., Polinder S., Pond C.D., Prakash V., Purwar M., Qorbani M., Quistberg D.A., Radfar A., Rafay A., Rahimi K., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rai R.K., Ram U., Rana S.M., Rankin Z., Rao P.V., Rao P.C., Rawaf S., Rego M.A.S., Reitsma M., Remuzzi G., Renzaho A.M.N.N., Resnikoff S., Rezaei S., Rezai M.S., Ribeiro A.L., Roba H.S., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Roy N.K., Sachdev P.S., Sackey B.B., Saeedi M.Y., Safiri S., Sagar R., Sahraian M.A., Saleh M.M., Salomon J.A., Samy A.M., Sanabria J.R., Sanchez-Niño M.D., Sandar L., Santos I.S., Santos J.V., Santric Milicevic M.M., Sarmiento-Suarez R., Sartorius B., Satpathy M., Savic M., Sawhney M., Saylan M.I., Schöttker B., Schutte A.E., Schwebel D.C., Seedat S., Seid A.M., Seifu C.N., Sepanlou S.G., Serdar B., Servan-Mori E.E., Setegn T., Shackelford K.A., Shaheen A., Shahraz S., Shaikh M.A., Shakh-Nazarova M., Shamsipour M., Shariful Islam S.M., Sharma J., Sharma R., She J., Sheikhbahaei S., Shen J., Shi P., Shigematsu M., Shin M.-J., Shiri R., Shoman H., Shrime M.G., Sibamo E.L.S., Sigfusdottir I.D., Silva D.A.S., Silveira D.G.A., Sindi S., Singh A., Singh J.A., Singh O.P., Singh P.K., Singh V., Sinke A.H., Sinshaw A.E., Skirbekk V., Sliwa K., Smith A., Sobngwi E., Soneji S., Soriano J.B., Sousa T.C.M., Sposato L.A., Sreeramareddy C.T., Stathopoulou V., Steel N., Steiner C., Steinke S., Stokes M.A., Stranges S., Strong M., Stroumpoulis K., Sturua L., Sufiyan M.B., Suliankatchi R.A., Sun J., Sur P., Swaminathan S., Sykes B.L., Tabarés-Seisdedos R., Tabb K.M., Taffere G.R., Talongwa R.T., Tarajia M., Tavakkoli M., Taveira N., Teeple S., Tegegne T.K., Tehrani-Banihashemi A., Tekelab T., Tekle D.Y., Temam Shifa G., Terkawi A.S., Tesema A.G., Thakur J.S., Thomson A.J., Tillmann T., Tiruye T.Y., Tobe-Gai R., Tonelli M., Topor-Madry R., Tortajada M., Troeger C., Truelsen T., Tura A.K., Uchendu U.S., Ukwaja K.N., Undurraga E.A., Uneke C.J., Uthman O.A., Van Boven J.F.M., Van Dingenen R., Varughese S., Vasankari T., Venketasubramanian N., Violante F.S., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Wagner J.A., Wakayo T., Waller S.G., Walson J.L., Wang H., Wang Y.-P., Watkins D.A., Weiderpass E., Weintraub R.G., Wen C.-P., Werdecker A., Wesana J., Westerman R., Whiteford H.A., Wilkinson J.D., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Won S., Workicho A., Workie S.B., Wubshet M., Xavier D., Xu G., Yadav A.K., Yaghoubi M., Yakob B., Yan L.L., Yano Y., Yaseri M., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Younis M.Z., Yu C., Zaidi Z., El Sayed Zaki M., Zambrana-Torrelio C., Zapata T., Zenebe Z.M., Zodpey S., Zoeckler L., Zuhlke L.J., Murray C.J.L., GBD 2015 Healthcare Access and Quality Collaborators (2017)

Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). ...
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19

Tsatsakis A., Calina D., Falzone L., Petrakis D., Mitrut R., Siokas V., Pennisi M., Lanza G., Libra M., Doukas S.G., Doukas P.G., Kavali L., Bukhari A., Gadiparthi C., Vageli D.P., Kofteridis D.P., Spandidos D.A., Paoliello M.M.B., Aschner M., Docea A.O. (2020)

Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to severe acute respiratory distress. The severity of the illness can also extend from mild disease to life-threatening acute respiratory ...