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dc.creatorLi, X.en
dc.creatorYoungren, J. F.en
dc.creatorHyun, B.en
dc.creatorSakkas, G. K.en
dc.creatorMulligan, K.en
dc.creatorMajumdar, S.en
dc.creatorMasharani, U. B.en
dc.creatorSchambelan, M.en
dc.creatorGoldfine, I. D.en
dc.date.accessioned2015-11-23T10:37:43Z
dc.date.available2015-11-23T10:37:43Z
dc.date.issued2008
dc.identifier10.1016/j.mri.2007.06.006
dc.identifier.issn0730725X
dc.identifier.urihttp://hdl.handle.net/11615/30279
dc.description.abstractObjectives: The objectives of this study were to develop protocols that measure abdominal fat and calf muscle lipids with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), respectively, at 3 T and to examine the correlation between these parameters and insulin sensitivity. Materials and Methods: Ten nondiabetic subjects [five insulin-sensitive (IS) subjects and five insulin-resistant (IR) subjects] were scanned at 3 T. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were segmented semiautomatically from abdominal imaging. Intramyocellular lipids (IMCL) in calf muscles were quantified with single-voxel MRS in both soleus and tibialis anterior muscles and with magnetic resonance spectroscopic imaging (MRSI). Results: The average coefficient of variation (CV) of VAT/(VAT+SAT) was 5.2%. The interoperator CV was 1.1% and 5.3% for SAT and VAT estimates, respectively. The CV of IMCL was 13.7% in soleus, 11.9% in tibialis anterior and 2.9% with MRSI. IMCL based on MRSI (3.8±1.2%) were significantly inversely correlated with glucose disposal rate, as measured by a hyperinsulinemic-euglycemic clamp. VAT volume correlated significantly with IMCL. IMCL based on MRSI for IR subjects was significantly greater than that for IS subjects (4.5±0.9% vs. 2.8±0.5%, P=.02). Conclusion: MRI and MRS techniques provide a robust noninvasive measurement of abdominal fat and muscle IMCL, which are correlated with insulin action in humans. © 2007 Elsevier Inc. All rights reserved.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-38349117488&partnerID=40&md5=b745e5cb2e98bd7469dce42b50cc6efb
dc.subjectAbdominal faten
dc.subjectInsulin sensitivityen
dc.subjectIntramyocellular lipids (IMCL)en
dc.subjectMagnetic resonance imaging (MRI)en
dc.subjectMagnetic resonance spectroscopy (MRS)en
dc.subjectadulten
dc.subjectarticleen
dc.subjectbody compositionen
dc.subjectclinical featureen
dc.subjectcontrolled studyen
dc.subjectenzyme linked immunosorbent assayen
dc.subjectfemaleen
dc.subjectglucose toleranceen
dc.subjecthumanen
dc.subjecthuman experimenten
dc.subjecthyperinsulinemiaen
dc.subjectin vivo studyen
dc.subjectinsulin resistanceen
dc.subjectmaleen
dc.subjectmuscle contractionen
dc.subjectnuclear magnetic resonance imagingen
dc.subjectnuclear magnetic resonance spectroscopyen
dc.subjectpriority journalen
dc.subjectHumansen
dc.subjectImage Processing, Computer-Assisteden
dc.subjectLegen
dc.subjectLipidsen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMagnetic Resonance Spectroscopyen
dc.subjectMiddle Ageden
dc.subjectMuscle, Skeletalen
dc.titleTechnical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 Ten
dc.typejournalArticleen


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