dc.creator | Li, X. | en |
dc.creator | Youngren, J. F. | en |
dc.creator | Hyun, B. | en |
dc.creator | Sakkas, G. K. | en |
dc.creator | Mulligan, K. | en |
dc.creator | Majumdar, S. | en |
dc.creator | Masharani, U. B. | en |
dc.creator | Schambelan, M. | en |
dc.creator | Goldfine, I. D. | en |
dc.date.accessioned | 2015-11-23T10:37:43Z | |
dc.date.available | 2015-11-23T10:37:43Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1016/j.mri.2007.06.006 | |
dc.identifier.issn | 0730725X | |
dc.identifier.uri | http://hdl.handle.net/11615/30279 | |
dc.description.abstract | Objectives: The objectives of this study were to develop protocols that measure abdominal fat and calf muscle lipids with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), respectively, at 3 T and to examine the correlation between these parameters and insulin sensitivity. Materials and Methods: Ten nondiabetic subjects [five insulin-sensitive (IS) subjects and five insulin-resistant (IR) subjects] were scanned at 3 T. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were segmented semiautomatically from abdominal imaging. Intramyocellular lipids (IMCL) in calf muscles were quantified with single-voxel MRS in both soleus and tibialis anterior muscles and with magnetic resonance spectroscopic imaging (MRSI). Results: The average coefficient of variation (CV) of VAT/(VAT+SAT) was 5.2%. The interoperator CV was 1.1% and 5.3% for SAT and VAT estimates, respectively. The CV of IMCL was 13.7% in soleus, 11.9% in tibialis anterior and 2.9% with MRSI. IMCL based on MRSI (3.8±1.2%) were significantly inversely correlated with glucose disposal rate, as measured by a hyperinsulinemic-euglycemic clamp. VAT volume correlated significantly with IMCL. IMCL based on MRSI for IR subjects was significantly greater than that for IS subjects (4.5±0.9% vs. 2.8±0.5%, P=.02). Conclusion: MRI and MRS techniques provide a robust noninvasive measurement of abdominal fat and muscle IMCL, which are correlated with insulin action in humans. © 2007 Elsevier Inc. All rights reserved. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-38349117488&partnerID=40&md5=b745e5cb2e98bd7469dce42b50cc6efb | |
dc.subject | Abdominal fat | en |
dc.subject | Insulin sensitivity | en |
dc.subject | Intramyocellular lipids (IMCL) | en |
dc.subject | Magnetic resonance imaging (MRI) | en |
dc.subject | Magnetic resonance spectroscopy (MRS) | en |
dc.subject | adult | en |
dc.subject | article | en |
dc.subject | body composition | en |
dc.subject | clinical feature | en |
dc.subject | controlled study | en |
dc.subject | enzyme linked immunosorbent assay | en |
dc.subject | female | en |
dc.subject | glucose tolerance | en |
dc.subject | human | en |
dc.subject | human experiment | en |
dc.subject | hyperinsulinemia | en |
dc.subject | in vivo study | en |
dc.subject | insulin resistance | en |
dc.subject | male | en |
dc.subject | muscle contraction | en |
dc.subject | nuclear magnetic resonance imaging | en |
dc.subject | nuclear magnetic resonance spectroscopy | en |
dc.subject | priority journal | en |
dc.subject | Humans | en |
dc.subject | Image Processing, Computer-Assisted | en |
dc.subject | Leg | en |
dc.subject | Lipids | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Magnetic Resonance Spectroscopy | en |
dc.subject | Middle Aged | en |
dc.subject | Muscle, Skeletal | en |
dc.title | Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T | en |
dc.type | journalArticle | en |