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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Activity of Oxacillin versus That of Vancomycin against Oxacillin-Susceptible mecA-Positive Staphylococcus aureus Clinical Isolates Evaluated by Population Analyses, Time-Kill Assays, and a Murine Thigh Infection Model

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Author
Labrou, M.; Michail, G.; Ntokou, E.; Pittaras, T. E.; Pournaras, S.; Tsakris, A.
Date
2012
DOI
10.1128/aac.00103-12
Keyword
METHICILLIN-RESISTANT
IN-VITRO
ENDOCARDITIS
PNEUMONIA
STRAINS
MRSA
Microbiology
Pharmacology & Pharmacy
Metadata display
Abstract
We compared the activity of dicloxacillin with that of vancomycin against 15 oxacillin-susceptible, methicillin-resistant Staphylococcus aureus (OS-MRSA) clinical isolates. By population analyses, we found that 6 OS-MRSA isolates were able to grow in the presence of up to 8 mu g/ml dicloxacillin and 9 isolates were able to grow in 12 to >32 mu g/ml dicloxacillin; all isolates grew in up to 2 mu g/ml vancomycin. Both drugs exhibited similar bactericidal activities. In experimental infections, the therapeutic efficacy of dicloxacillin was significant (P<0.05 versus untreated controls) in 10 OS-MRSA isolates and vancomycin was effective (P < 0.05) against 12 isolates; didoxacillin had an efficacy that was comparable to that of vancomycin (P>0.05) in 8 isolates. The favorable response to dicloxacillin treatment might suggest that antistaphylococcal penicillins could be used against OS-MRSA infections.
URI
http://hdl.handle.net/11615/30142
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19672]
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Η δικτυακή πύλη της Ευρωπαϊκής Ένωσης
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