dc.creator | Koutsoumpas, A. L. | en |
dc.creator | Kriese, S. | en |
dc.creator | Rigopoulou, E. I. | en |
dc.date.accessioned | 2015-11-23T10:36:55Z | |
dc.date.available | 2015-11-23T10:36:55Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1007/s13317-012-0039-y | |
dc.identifier.issn | 20380305 | |
dc.identifier.uri | http://hdl.handle.net/11615/29995 | |
dc.description.abstract | Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the autoimmune destruction of the biliary epithelial cells of the small and medium-size bile ducts. The disease affects middle aged women and usually affects more than one member within a family. The pathognomonic serological hallmark of the disease is the presence of circulating anti-mitochondrial antibodies, and disease-specific anti-nuclear antibodies. Susceptibility genes and environmental risk factors such as infections and smoking have been reported as important for the development of the disease. Among the environmental agents, infectious triggers are the best studied. Most of the work published so far has investigated the role of infections caused by Novosphingobium aromaticivorans and Escherichia coli. This review will discuss the popular and unpopular infectious agents causatively linked to PBC. It will also examine reports investigating the epidemiological aspects of the disease and their direct or indirect implications to bacterial-induced PBC. © 2012 Springer-Verlag Italia. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84870478326&partnerID=40&md5=1023c00912279d393369e5db0541040f | |
dc.subject | Autoimmune disease | en |
dc.subject | Autoimmunity | en |
dc.subject | Bile ducts | en |
dc.subject | Cholestasis | en |
dc.subject | Cross-reactivity | en |
dc.subject | Immunity | en |
dc.subject | Liver | en |
dc.subject | Mimicry | en |
dc.subject | Tolerance | en |
dc.subject | 2 oxoisovalerate dehydrogenase (lipoamide) | en |
dc.subject | antinuclear antibody | en |
dc.subject | bacterial protein | en |
dc.subject | mitochondrion antibody | en |
dc.subject | oxoglutarate dehydrogenase | en |
dc.subject | pyruvate dehydrogenase complex | en |
dc.subject | Acholeplasma laidlawii | en |
dc.subject | antibiotic therapy | en |
dc.subject | antibody detection | en |
dc.subject | atypical Mycobacterium | en |
dc.subject | Azotobacter vinelandii | en |
dc.subject | Bacillus subtilis | en |
dc.subject | Bacillus thuringiensis | en |
dc.subject | bile duct | en |
dc.subject | Chlamydophila pneumoniae | en |
dc.subject | clinical feature | en |
dc.subject | Cytomegalovirus | en |
dc.subject | disease activity | en |
dc.subject | ecotropic virus | en |
dc.subject | environmental factor | en |
dc.subject | epithelium cell | en |
dc.subject | Epstein Barr virus | en |
dc.subject | Escherichia coli | en |
dc.subject | genetic susceptibility | en |
dc.subject | Gram negative bacterium | en |
dc.subject | Haemophilus influenzae | en |
dc.subject | Helicobacter | en |
dc.subject | Helicobacter pylori | en |
dc.subject | Histoplasma capsulatum | en |
dc.subject | human | en |
dc.subject | Human cytomegalovirus | en |
dc.subject | immunopathogenesis | en |
dc.subject | infection | en |
dc.subject | infection risk | en |
dc.subject | Lactobacillus | en |
dc.subject | Lactobacillus delbrueckii | en |
dc.subject | middle aged | en |
dc.subject | molecular epidemiology | en |
dc.subject | molecular mimicry | en |
dc.subject | Mycobacterium | en |
dc.subject | natural killer T cell | en |
dc.subject | Neisseria meningitidis | en |
dc.subject | Neurospora crassa | en |
dc.subject | nonhuman | en |
dc.subject | Novosphingobium aromaticivorans | en |
dc.subject | primary biliary cirrhosis | en |
dc.subject | priority journal | en |
dc.subject | protein function | en |
dc.subject | Pseudomonas aeruginosa | en |
dc.subject | Pseudomonas putida | en |
dc.subject | Retrovirus | en |
dc.subject | review | en |
dc.subject | risk assessment | en |
dc.subject | sex difference | en |
dc.subject | smoking | en |
dc.subject | Streptomyces aureofaciens | en |
dc.title | Popular and unpopular infectious agents linked to primary biliary cirrhosis | en |
dc.type | journalArticle | en |