Role of Histamine in Altering Fluid Recycling in Normal and Post-Traumatic Rabbit Peritoneum
dc.creator | Kouritas, V. K. | en |
dc.creator | Tepetes, K. | en |
dc.creator | Spyridakis, M. | en |
dc.creator | Theodosopoulou, K. V. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.creator | Molyvdas, P. A. | en |
dc.creator | Hatzoglou, C. | en |
dc.date.accessioned | 2015-11-23T10:36:23Z | |
dc.date.available | 2015-11-23T10:36:23Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1007/s10753-013-9767-z | |
dc.identifier.issn | 0360-3997 | |
dc.identifier.uri | http://hdl.handle.net/11615/29864 | |
dc.description.abstract | This study aims to investigate if histamine induces electrochemical alterations in the normal and post-traumatic peritoneum. Peritoneal rabbit specimens were obtained before surgery and 10 days post-operatively and were mounted in Ussing chambers. Histamine solutions were added facing the intra-peritoneal and outer-peritoneal surface. Dimetindene maleate-, cetirizine-, and ranitidine-pretreated specimens were used to investigate histamine receptor involvement, whereas amiloride- and ouabain-pretreated specimens were used to investigate ion transportation blockage involvement. Trans-mesothelial resistance (R (TM) ) was determined. Histamine-increased R (TM) intra-peritoneally and decreased it outer-peritoneally. A less intense effect was induced in post-traumatic specimens. Dimetindene maleate, cetirizine, amiloride, and ouabain totally inhibited this effect, whereas ranitidine only had a partial effect. Histamine induces electrochemical alterations in the normal and post-operative peritoneum. This effect is mediated by interaction with histamine receptors, hindering the normal process of ion trans-mesothelial transportation. | en |
dc.source | Inflammation | en |
dc.source.uri | <Go to ISI>://WOS:000332715000028 | |
dc.subject | histamine | en |
dc.subject | peritoneum | en |
dc.subject | fluid recycling | en |
dc.subject | surgical trauma | en |
dc.subject | ion | en |
dc.subject | transportation | en |
dc.subject | BLOOD-BRAIN-BARRIER | en |
dc.subject | EPITHELIAL PERMEABILITY | en |
dc.subject | INFLAMMATORY MEDIATORS | en |
dc.subject | ELECTRICAL-RESISTANCE | en |
dc.subject | SURGICAL TRAUMA | en |
dc.subject | ION-TRANSPORT | en |
dc.subject | CELLS | en |
dc.subject | COLON | en |
dc.subject | MECHANISMS | en |
dc.subject | AMILORIDE | en |
dc.subject | Cell Biology | en |
dc.subject | Immunology | en |
dc.title | Role of Histamine in Altering Fluid Recycling in Normal and Post-Traumatic Rabbit Peritoneum | en |
dc.type | journalArticle | en |
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