The relationship between Rarebit perimetry and OCT-derived retinal nerve fibre layer thickness in glaucoma

Abstract

To examine the association between measures of neuroretinal matrix integrity as determined with Rarebit perimetry and optical coherence tomography (OCT)-derived retinal nerve fibre layer thickness. One randomly selected eye of 30 White primary open-angle glaucoma patients (age: 60.9 +/- 11.7 years; MD: -3.2 +/- 5.1 dB) and 16 healthy White individuals (age: 33.2 +/- 6.4 years; MD: -0.8 +/- 0.8 dB) were included in the study. Participants underwent Rarebit perimetry testing (central field, software version 4) and an OCT fast retinal nerve fibre layer (RNFL) scan. Correlation was investigated between hemifield Rarebit scores and the corresponding RNFL values, as well as between global Rarebit scores and the respective RNFL measures. Statistically significant correlations of average hit rate (HR) < 90 and mean hit rate (MHR) were detected with Max-Min and average thickness (Pearson's r ranging from 0.393 to 0.474). Number HR < 90 showed a moderate correlation only with Max-Min (r = -0.396, P = 0.030). Regarding the association between hemifield hit rates and the corresponding OCT thickness parameters, only inferior maximum correlated moderately with HR superior (r = 0.385, P = 0.035). A tendency was detected for the relationship of superior maximum with HR inferior (r = 0.345, P = 0.062). For the control group, no significant correlation was found for any of the global or hemifield indices and the corresponding thickness values. Although Rarebit perimetry is based on a physiological principle distinctly different from conventional perimetry, it provides global indicators of neuroretinal matrix integrity that correlate with some OCT-derived RNFL thickness measures.