dc.creator | Kapsimalis, F. | en |
dc.creator | Basta, M. | en |
dc.creator | Varouchakis, G. | en |
dc.creator | Gourgoulianis, K. | en |
dc.creator | Vgontzas, A. | en |
dc.creator | Kryger, M. | en |
dc.date.accessioned | 2015-11-23T10:32:40Z | |
dc.date.available | 2015-11-23T10:32:40Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1016/j.sleep.2007.08.019 | |
dc.identifier.issn | 13899457 | |
dc.identifier.uri | http://hdl.handle.net/11615/28900 | |
dc.description.abstract | Cytokines are proteins produced by leukocytes and other cells that function as intercellular mediators acting on several target tissues, resulting in multiple biologic actions. Over the last decade, medical research has explored the interaction between cytokines and sleep disorders. The aim of this review is to illustrate recent advances in knowledge about the relationship between cytokines and disorders of excessive sleepiness. Cytokines may have an important role in mediating excessive daytime sleepiness in sleep loss or insomnia. Alterations of the immune system have also been associated with narcolepsy. The relationship between cytokines and hormonal regulatory mechanisms may explain symptoms like fatigue and sleepiness in chronic inflammatory diseases. Cytokines may play an important role in the pathogenesis of obstructive sleep apnea and cardiovascular consequences of this condition. New biologic treatments targeting cytokines have been investigated in conditions characterized by sleep disturbance. © 2007 Elsevier B.V. All rights reserved. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-48449086888&partnerID=40&md5=0c7b83d78c12d6672293e0fb9d1ceb89 | |
dc.subject | Cytokines | en |
dc.subject | Excessive daytime sleepiness | en |
dc.subject | Inflammation | en |
dc.subject | Insomnia | en |
dc.subject | Insulin resistance | en |
dc.subject | Narcolepsy | en |
dc.subject | Sleep apnea | en |
dc.subject | Sleep deprivation | en |
dc.subject | adiponectin | en |
dc.subject | C reactive protein | en |
dc.subject | corticotropin | en |
dc.subject | cytokine | en |
dc.subject | etanercept | en |
dc.subject | ghrelin | en |
dc.subject | growth hormone | en |
dc.subject | growth hormone releasing factor | en |
dc.subject | HLA antigen class 2 | en |
dc.subject | HLA DR2 antigen | en |
dc.subject | hydrocortisone | en |
dc.subject | immunoglobulin enhancer binding protein | en |
dc.subject | inducible nitric oxide synthase | en |
dc.subject | infliximab | en |
dc.subject | intercellular adhesion molecule 1 | en |
dc.subject | interleukin 1 | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 1beta | en |
dc.subject | interleukin 2 | en |
dc.subject | interleukin 6 | en |
dc.subject | leptin | en |
dc.subject | neuronal nitric oxide synthase | en |
dc.subject | resistin | en |
dc.subject | transforming growth factor beta | en |
dc.subject | tumor necrosis factor alpha | en |
dc.subject | tumor necrosis factor receptor | en |
dc.subject | vasculotropin | en |
dc.subject | anorexia | en |
dc.subject | cancer immunotherapy | en |
dc.subject | cardiovascular disease | en |
dc.subject | cardiovascular risk | en |
dc.subject | cytokine production | en |
dc.subject | cytokine release | en |
dc.subject | daytime somnolence | en |
dc.subject | depression | en |
dc.subject | drug efficacy | en |
dc.subject | drug induced headache | en |
dc.subject | head and neck surgery | en |
dc.subject | human | en |
dc.subject | myalgia | en |
dc.subject | neoplasm | en |
dc.subject | neuroendocrine system | en |
dc.subject | nonhuman | en |
dc.subject | obesity | en |
dc.subject | pathogenesis | en |
dc.subject | positive end expiratory pressure | en |
dc.subject | priority journal | en |
dc.subject | protein expression | en |
dc.subject | protein function | en |
dc.subject | review | en |
dc.subject | signal transduction | en |
dc.subject | sleep apnea syndrome | en |
dc.subject | sleep disorder | en |
dc.subject | sleep waking cycle | en |
dc.subject | somnolence | en |
dc.subject | therapy effect | en |
dc.subject | Cardiovascular Diseases | en |
dc.subject | Disorders of Excessive Somnolence | en |
dc.subject | Humans | en |
dc.subject | Risk Factors | en |
dc.title | Cytokines and pathological sleep | en |
dc.type | journalArticle | en |