Effect of gonadotrophin-releasing hormone agonist treatment on growth hormone secretion in women with polycystic ovarian syndrome
Ημερομηνία
1998Λέξη-κλειδί
Επιτομή
The suppression of the pituitary-gonadal axis by the administration of gonadotrophin-releasing hormone agonists (GnRH-a) is used occasionally as an adjunct therapy with gonadotrophins for ovulation induction in women with polycystic ovarian syndrome (PCOS), A number of recent clinical studies have suggested that women with polycystic ovaries (PCO) may have disturbances of normal growth hormone (GH) kinetics and alterations in the GH/insulin-like growth factor (IGF)-I system, The purpose of this study was to determine the effect of GnRH-a administration on GH-releasing hormone (GHRH)-stimulated GH release in women with PCOS, Eight women with PCO and six control women were studied before and after 2 months of treatment with the long acting GnRH-a triptoreline (3.75 mg monthly injections), GHRH was given as a single i.v. injection and blood samples for GH measurements were obtained at -15, 0, 30, 60, 90 and 120 min, The GH responses were expressed as the area under the curve (AUC) or the differences from the basal value (Delta(max)). The GH response to GHRH (mean +/- SEM) was lower in women with PCO (AUG 114.9 +/- 43.1 versus 206.2 +/- 28.7 ng/ml/120 min, P < 0.05 and Delta(max) 31.6 +/- 8.2 versus 49.4 +/- 5.8 ng/ml,P < 0.05), After treatment with the GnRH-a, the GH response to GHRH was significantly smaller than before treatment in both groups (PCO AUC 34.6 +/- 9.0 ng/ml/120 min and Delta(max) 12.4 +/- 3.1 ng/ml; controls AUC 148.8 +/- 28.4 ng/ml/120 min and Delta(max) 31.2 +/- 6.1 ng/ml), but the PCO group had a significantly smaller response, These data demonstrate that women with PCO have a reduced GH response to GHRH compared with normal controls and that GnRH-a administration causes a further GH reduction in both groups, Women with PCO have a greater suppression of GH response to GHRH during treatment with GnRH-a, This suggests that a different level of sensitivity in the somatotrophic axis exists in PCOS.
Collections
Related items
Showing items related by title, author, creator and subject.
-
The effect of a GnRH antagonist on follicle maturation in normal women
Pousias S., Messini C.I., Anifandis G., Sveronis G., Georgoulias P., Daponte A., Messinis I.E., Dafopoulos K. (2019)Research question: Ganirelix is a gonadotrophin-releasing hormone (GnRH) antagonist used for the prevention of premature LH surge during ovarian stimulation. What is the impact of ganirelix on follicle maturation in normal ... -
Biology of the steroid hormone receptor superfamily
Vamvakopoulos, N. C. (1996)Following a brief introduction to the Biology (structure-function) of the steroid hormone receptor superfamily, an updated summary of pathogenic mutations in the steroid, thyroid hormone and vitamin D receptors causing ... -
Ghrelin suppresses the GnRH-induced preovulatory gonadotropin surge in dairy heifers
Chouzouris T.M., Dovolou E., Dafopoulos K., Georgoulias P., Vasileiou N.G., Fthenakis G.C., Anifandis G., Amiridis G.S. (2016)Ghrelin, a known growth hormone (GH) secretagogue, alters gonadotropin secretion in many species. Our objectives were to study the effects of ghrelin, on GH, LH, FSH secretion, and on luteal function of the ensuing estrous ...