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Kinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors: Effect of antibiotics on RNase P

dc.creatorKalavrizioti, D.en
dc.creatorVourekas, A.en
dc.creatorTekos, A.en
dc.creatorTsagla, A.en
dc.creatorStathopoulos, C.en
dc.creatorDrainas, D.en
dc.date.accessioned2015-11-23T10:31:00Z
dc.date.available2015-11-23T10:31:00Z
dc.date.issued2003
dc.identifier10.1023/A:1022290110116
dc.identifier.issn3014851
dc.identifier.urihttp://hdl.handle.net/11615/28757
dc.description.abstractA cell-free system derived from Dictyostelium discoideum has been used to study the kinetics of inhibition of RNase P by puromycin, amicetin and blasticidin S. Detailed kinetic analysis showed that the type of inhibition of RNase P activity by puromycin is simple competitive, whereas the type of inhibition by amicetin and blasticidin S is simple non-competitive. On the basis of Ki values amicetin is stronger inhibitor than puromycin and blasticidin S.en
dc.sourceMolecular Biology Reportsen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-0037335175&partnerID=40&md5=2df686e55f0be5c3b51e0e1f6dd27821
dc.subjectProtein synthesis inhibitorsen
dc.subjectRibozymesen
dc.subjectRNase Pen
dc.subjectamicetinen
dc.subjectantibiotic agenten
dc.subjectblasticidin Sen
dc.subjectpeptidyltransferaseen
dc.subjectpuromycinen
dc.subjectribonuclease Pen
dc.subjectunclassified drugen
dc.subjectarticleen
dc.subjectcell free systemen
dc.subjectcompetitive inhibitionen
dc.subjectconcentration responseen
dc.subjectcontrolled studyen
dc.subjectenzyme activityen
dc.subjectenzyme inhibitionen
dc.subjectkineticsen
dc.subjectnonhumanen
dc.subjectAnimalsen
dc.subjectDictyosteliumen
dc.subjectDose-Response Relationship, Drugen
dc.subjectEndoribonucleasesen
dc.subjectNucleosidesen
dc.subjectPeptidyl Transferasesen
dc.subjectPyrimidine Nucleosidesen
dc.subjectRNA, Catalyticen
dc.subjectDictyostelium discoideumen
dc.subjectProtozoaen
dc.titleKinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors: Effect of antibiotics on RNase Pen
dc.typejournalArticleen


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