Efficacy of Interferon A-2b Monotherapy in B-Thalassemics with Chronic Hepatitis C
dc.creator | Kalafateli, M. | en |
dc.creator | Kourakli, A. | en |
dc.creator | Gatselis, N. | en |
dc.creator | Lambropoulou, P. | en |
dc.creator | Thomopoulos, K. | en |
dc.creator | Tsamandas, A. | en |
dc.creator | Christofidou, M. | en |
dc.creator | Zachou, K. | en |
dc.creator | Jelastopoulou, E. | en |
dc.creator | Nikolopoulou, V. | en |
dc.creator | Symeonidis, A. | en |
dc.creator | Dalekos, G. N. | en |
dc.creator | Lambropoulou-Karatza, C. | en |
dc.creator | Triantos, C. | en |
dc.date.accessioned | 2015-11-23T10:30:58Z | |
dc.date.available | 2015-11-23T10:30:58Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1841-8724 | |
dc.identifier.uri | http://hdl.handle.net/11615/28746 | |
dc.description.abstract | Background & Aims: Monotherapy with standard or pegylated interferon (PegIFN) remains the first-line treatment for HCV infection in patients with thalassemia major (beta TM), although its long-term impact is still unknown. We aimed to assess the efficacy of IFN-a2b/PegIFN-a2b (one or multiple treatment sessions) and the predictors for sustained virological response (SVR) in HCV-infected beta TM patients. Methods: Between 11/1992 and 12/2013 [median follow-up: 165.5 months (8-237)1, 48 beta TM HCV-infected patients [19 males, median age: 22 years (12-45)], received IFN-a2b (n=34) or PegIFN-a2b (n=14). Twenty-three patients (47.9%) had a previous splenectomy; 13/40 (32.5%) patients had Ishak stage >= 4 and 21/40 (52.5%) had siderosis grade 3-4. HCV-genotype was available in 36 patients (genotype I: 47.2%, 2: 5.6%, 3: 25%, and 4: 22%). IL28B genotype was determined in 37 patients by means of in-house real-time PCR (CC: 27%, CT: 62.2%, TT: 10.8%). Results: Totally, 15/48 (31.3%) achieved SVR following the first treatment and 18/48 (37.5%) after multiple courses. Splenectomy (p=0.01) and fibrosis grade >= 4 (p<0.05) were negative predictors for SVR (first course), whereas splenectomy (p<0.05) and age >18 (p<0.02) for SVR after multiple courses. In HCV-genotype 1/4 (n=25), none of the patients with CT or TT IL28B genotype achieved SVR compared to 50% of the CC patients (p=0.004). Conclusions: Interferon is an effective therapeutic option in HCV-infected beta TM patients. IL28B genotype was a strong predictor for SVR, together with splenectomy, age and fibrosis. | en |
dc.source | Journal of Gastrointestinal and Liver Diseases | en |
dc.source.uri | <Go to ISI>://WOS:000357147900014 | |
dc.subject | thalassemia major | en |
dc.subject | chronic hepatitis C | en |
dc.subject | interferon | en |
dc.subject | pegylated | en |
dc.subject | IL28B polymorphisms | en |
dc.subject | HOMOZYGOUS BETA-THALASSEMIA | en |
dc.subject | INDUCED VIRAL CLEARANCE | en |
dc.subject | CHRONIC HCV | en |
dc.subject | INFECTION | en |
dc.subject | ALPHA-INTERFERON | en |
dc.subject | VIRUS-INFECTION | en |
dc.subject | IRON OVERLOAD | en |
dc.subject | COMBINATION | en |
dc.subject | THERAPY | en |
dc.subject | GENETIC-VARIATION | en |
dc.subject | MAJOR PATIENTS | en |
dc.subject | LIVER-DISEASE | en |
dc.subject | Gastroenterology & Hepatology | en |
dc.title | Efficacy of Interferon A-2b Monotherapy in B-Thalassemics with Chronic Hepatitis C | en |
dc.type | journalArticle | en |
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