dc.creator | Hatziefthimiou, A. A. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.creator | Molyvdas, P. A. | en |
dc.date.accessioned | 2015-11-23T10:29:59Z | |
dc.date.available | 2015-11-23T10:29:59Z | |
dc.date.issued | 2002 | |
dc.identifier | 10.1080/09629350120117275 | |
dc.identifier.issn | 0962-9351 | |
dc.identifier.uri | http://hdl.handle.net/11615/28454 | |
dc.description.abstract | WE, investigated the effect of the excitatory amino acid (EAA) receptor agonists L-glutamate, N-methyl-D-aspartate (NMDA), (RS)-a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainic acid on KCl-induced contractions of rabbit tracheal smooth muscle, as well as the role of epithelium and endogenously produced nitric oxide and prostaglandins on these responses. L-Glutamate decreased KCl-induced contractions up to 30%. This effect was attenuated by epithelium removal, tetrodotoxin, methylene blue and indomethacin but not by N-vitro-L-arginine methyl ester. While NMDA, AMPA and kainic acid had no effect, the combination of NMDA + kainic acid decreased KCl-induced contractions. These results suggest that, in rabbit trachea, L-glutamate has, at least in part, an epithelium-dependent effect mediated via prostaglandin formation and that the EAA receptors involved are non-classical. | en |
dc.source.uri | <Go to ISI>://WOS:000174570300006 | |
dc.subject | airway smooth muscle | en |
dc.subject | rabbit | en |
dc.subject | L-glutamate | en |
dc.subject | prostaglandins | en |
dc.subject | EAA receptors | en |
dc.subject | VASOACTIVE-INTESTINAL-PEPTIDE | en |
dc.subject | NONCHOLINERGIC INHIBITORY SYSTEM | en |
dc.subject | PLASMA-PROTEIN EXTRAVASATION | en |
dc.subject | ALLERGEN SENSITIZED RABBITS | en |
dc.subject | D-ASPARTATE | en |
dc.subject | RECEPTORS | en |
dc.subject | GUINEA-PIG | en |
dc.subject | SUBSTANCE-P | en |
dc.subject | NMDA RECEPTOR | en |
dc.subject | SMOOTH-MUSCLE | en |
dc.subject | NEUTRAL ENDOPEPTIDASE | en |
dc.subject | Cell Biology | en |
dc.subject | Immunology | en |
dc.title | Epithelium-dependent effect of L-glutamate on airways: involvement of prostaglandins | en |
dc.type | journalArticle | en |