IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury
dc.creator | Hadjigeorgiou, G. M. | en |
dc.creator | Paterakis, K. | en |
dc.creator | Dardiotis, E. | en |
dc.creator | Dardioti, M. | en |
dc.creator | Aggelakis, K. | en |
dc.creator | Tasiou, A. | en |
dc.creator | Xiromerisiou, G. | en |
dc.creator | Komnos, A. | en |
dc.creator | Zintzaras, E. | en |
dc.creator | Scarmeas, N. | en |
dc.creator | Papadimitriou, A. | en |
dc.creator | Karantanas, A. | en |
dc.date.accessioned | 2015-11-23T10:29:23Z | |
dc.date.available | 2015-11-23T10:29:23Z | |
dc.date.issued | 2005 | |
dc.identifier | 10.1212/01.wnl.0000178890.93795.0e | |
dc.identifier.issn | 0028-3878 | |
dc.identifier.uri | http://hdl.handle.net/11615/28288 | |
dc.description.abstract | Objective: To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI). Methods: Data from brain CT, Glasgow Coma Scale (GCS) at admission, and 6-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) were collected for 151 prospectively recruited patients with TBI. IL-1RN and IL-1B genotypes were determined using standard methods. Presence vs absence of any type of brain hemorrhage was the main outcome. Type of brain hemorrhage, GCS at admission, and 6-month GOS and mRS were secondary outcomes. Odd ratios (ORs) and corresponding 95% CI were calculated using logistic regression analyses. In adjusted models, the associations were controlled for age, gender, diffuse brain edema, volume of intracranial hematoma, neurosurgical intervention, and GCS at admission. p values less than 0.01 were considered significant. Results: Compared with noncarriers, IL-1RN allele 2 carriers had higher odds of having cerebral hemorrhages after TBI ( adjusted OR = 4.57; 95% CI = 1.67 to 12.96; p = 0.004). The associations for (-511) IL-1B polymorphism were not significant. Conclusion: There is an association between the presence of interleukin-1RN allele 2 and posttraumatic brain hemorrhage. | en |
dc.source | Neurology | en |
dc.source.uri | <Go to ISI>://WOS:000232470200020 | |
dc.subject | INTERLEUKIN-1 RECEPTOR ANTAGONIST | en |
dc.subject | HUMAN-ENDOTHELIAL-CELLS | en |
dc.subject | SEVERE | en |
dc.subject | HEAD-INJURY | en |
dc.subject | MULTIPLE-SCLEROSIS | en |
dc.subject | HUMAN MONOCYTES | en |
dc.subject | INNATE IMMUNE | en |
dc.subject | ASSOCIATION | en |
dc.subject | DISEASE | en |
dc.subject | INFLAMMATION | en |
dc.subject | COAGULATION | en |
dc.subject | Clinical Neurology | en |
dc.title | IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury | en |
dc.type | journalArticle | en |
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