Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment
dc.creator | Grabowski, J. | en |
dc.creator | Yurdaydìn, C. | en |
dc.creator | Zachou, K. | en |
dc.creator | Buggisch, P. | en |
dc.creator | Hofmann, W. P. | en |
dc.creator | Jaroszewicz, J. | en |
dc.creator | Schlaphoff, V. | en |
dc.creator | Manns, M. P. | en |
dc.creator | Cornberg, M. | en |
dc.creator | Wedemeyer, H. | en |
dc.date.accessioned | 2015-11-23T10:29:08Z | |
dc.date.available | 2015-11-23T10:29:08Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1111/j.1478-3231.2011.02593.x | |
dc.identifier.issn | 14783223 | |
dc.identifier.uri | http://hdl.handle.net/11615/28179 | |
dc.description.abstract | Background: Hepatitis delta is caused by infection with the hepatitis D virus (HDV) and is considered the most severe form of viral hepatitis. Treatment options for hepatitis delta are limited, with only 25% of patients responding to interferon (IFN)-alfa-based therapies. The role of the adaptive immune system in controlling HDV infection during spontaneous or treatment-induced viral clearance is not well understood. Methods: We studied HDV-specific cytokine production of peripheral blood mononuclear cells stimulated with HDV peptide pools as well as serum cytokine levels in well-characterized patients with chronic HDV infection before and during pegylated-interferon-alfa±adefovir therapy. Results: Hepatitis D virus-specific interleukin (IL)-2, IFN-γ-, interferon-inducible protein-10 and IL-10-responses were detectable in 53%, 35%, 65% and 6% of hepatitis delta patients. HDV-specific IFN-γ responses tended to be more common in patients with low HDV viral loads. HDV-specific cytokine responses declined during pegylated (PEG)-IFNa therapy and patterns of changes were associated with the treatment response. Serum cytokine levels also showed distinct changes during PEG-IFNa treatment. Conclusion: We suggest that cellular HDV-specific immune responses contribute to the control of HDV infection and that cytokine responses may indicate response to type-I-IFN-based antiviral therapy of hepatitis delta. © 2011 John Wiley & Sons A/S. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-80052525365&partnerID=40&md5=31c86167d8f22aa1c912d18372ee902f | |
dc.subject | Cellular immune responses | en |
dc.subject | Delta hepatitis | en |
dc.subject | HDV | en |
dc.subject | IFNα treatment | en |
dc.subject | Interferon-alfa-2a | en |
dc.subject | IP-10 | en |
dc.subject | adefovir | en |
dc.subject | gamma interferon | en |
dc.subject | gamma interferon inducible protein 10 | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 2 | en |
dc.subject | peginterferon alpha | en |
dc.subject | adaptive immunity | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | article | en |
dc.subject | cell stimulation | en |
dc.subject | cellular immunity | en |
dc.subject | clinical article | en |
dc.subject | combination chemotherapy | en |
dc.subject | cytokine response | en |
dc.subject | delta agent hepatitis | en |
dc.subject | female | en |
dc.subject | Hepatitis delta virus | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | male | en |
dc.subject | monotherapy | en |
dc.subject | peripheral blood mononuclear cell | en |
dc.subject | treatment response | en |
dc.subject | viral clearance | en |
dc.subject | virus load | en |
dc.subject | Adenine | en |
dc.subject | Analysis of Variance | en |
dc.subject | Antiviral Agents | en |
dc.subject | Cells, Cultured | en |
dc.subject | Chi-Square Distribution | en |
dc.subject | Cytokines | en |
dc.subject | Drug Therapy, Combination | en |
dc.subject | Europe | en |
dc.subject | Hepatitis D, Chronic | en |
dc.subject | Humans | en |
dc.subject | Interferon-alpha | en |
dc.subject | Leukocytes, Mononuclear | en |
dc.subject | Middle Aged | en |
dc.subject | Organophosphonates | en |
dc.subject | Polyethylene Glycols | en |
dc.subject | Recombinant Proteins | en |
dc.subject | RNA, Viral | en |
dc.subject | Time Factors | en |
dc.subject | Treatment Outcome | en |
dc.subject | Viral Load | en |
dc.subject | Young Adult | en |
dc.title | Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment | en |
dc.type | journalArticle | en |
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