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dc.creatorGeorgakilas, A. G.en
dc.creatorPavlopoulou, A.en
dc.creatorLouka, M.en
dc.creatorNikitaki, Z.en
dc.creatorVorgias, C. E.en
dc.creatorBagos, P. G.en
dc.creatorMichalopoulos, I.en
dc.date.accessioned2015-11-23T10:27:30Z
dc.date.available2015-11-23T10:27:30Z
dc.date.issued2015
dc.identifier10.1016/j.canlet.2015.03.021
dc.identifier.issn3043835
dc.identifier.urihttp://hdl.handle.net/11615/27726
dc.description.abstractEfficient radiation therapy is characterized by enhanced tumor cell killing involving the activation of the immune system (tumor immunogenicity) but at the same time minimizing chronic inflammation and radiation adverse effects in healthy tissue. The aim of this study was to identify gene products involved in immune and inflammatory responses upon exposure to ionizing radiation by using various bioinformatic tools. Ionizing radiation is known to elicit different effects at the level of cells and organism i.e. DNA Damage Response (DDR), DNA repair, apoptosis and, most importantly, systemic effects through the instigation of inflammatory 'danger' signals and innate immune response activation. Genes implicated both in radiation and immune/inflammatory responses were collected manually from the scientific literature with a combination of relevant keywords. The experimentally validated and literature-based results were inspected, and genes involved in radiation, immune and inflammatory response were pooled. This kind of analysis was performed for the first time, for both healthy and tumor tissues. In this way, a set of 24 genes common in all three different phenomena was identified. These genes were found to form a highly connected network. Useful conclusions are drawn regarding the potential application of these genes as markers of response to radiation for both healthy and tumor tissues through the modulation of immune and/or inflammatory mechanisms. © 2015 Elsevier Ireland Ltd.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84941877398&partnerID=40&md5=85ef9e477c4baa249bace14b482e436f
dc.subjectBioinformaticsen
dc.subjectBiomarkersen
dc.subjectImmune responseen
dc.subjectInflammatory responseen
dc.subjectIonizing radiationen
dc.subjectPathwaysen
dc.subjectapoptosisen
dc.subjectcancer radiotherapyen
dc.subjectDNA damageen
dc.subjectDNA repairen
dc.subjectgene identificationen
dc.subjectgene producten
dc.subjectgenetic markeren
dc.subjecthumanen
dc.subjectimmunogenicityen
dc.subjectinflammationen
dc.subjectinnate immunityen
dc.subjectmolecular dynamicsen
dc.subjectnonhumanen
dc.subjectpriority journalen
dc.subjectprotein interactionen
dc.subjectradiation exposureen
dc.subjectShort Surveyen
dc.subjectsignal transductionen
dc.titleEmerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approachesen
dc.typejournalArticleen


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