dc.creator | Gatselis, N. K. | en |
dc.creator | Zachou, K. | en |
dc.creator | Papamichalis, P. | en |
dc.creator | Koukoulis, G. K. | en |
dc.creator | Gabeta, S. | en |
dc.creator | Dalekos, G. N. | en |
dc.creator | Rigopoulou, E. I. | en |
dc.date.accessioned | 2015-11-23T10:27:04Z | |
dc.date.available | 2015-11-23T10:27:04Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1016/j.dld.2010.03.005 | |
dc.identifier.issn | 1590-8658 | |
dc.identifier.uri | http://hdl.handle.net/11615/27680 | |
dc.description.abstract | Background and aims: The International Autoimmune Hepatitis Group developed a simplified score for autoimmune hepatitis. We assessed this "new scoring system" and compared it with the International Autoimmune Hepatitis Group original revised score. Methods: 502 patients were evaluated namely, 428 had liver diseases of various etiology [hepatitis B (n=109), hepatitis C (n=100), hepatitis D (n=4), alcoholic liver disease (n=28), non-alcoholic fatty liver disease (n=55), autoimmune cholestatic diseases (n=77), liver disorders of undefined origin (n=32) and miscellaneous hepatic disorders (n=23)], 13 had autoimmune hepatitis/overlap syndromes, 18 had autoimmune hepatitis/concurrent with other liver diseases and 43 had autoimmune hepatitis. Results: The specificity of the simplified score was similar to that of the revised score (97% vs. 97.9%). The sensitivity in unmasking autoimmune hepatitis in autoimmune hepatitis/overlap syndromes was also similar in both systems (53.8% and 61.5%). However, the sensitivity for autoimmune hepatitis diagnosis in autoimmune hepatitis patients with concurrent liver disorders was lower by the new score (p=0.001). Liver biopsy proved to be the only independent factor for unmasking autoimmune hepatitis component among patients (p=0.003). Conclusion: The simplified score is a reliable and simple tool for excluding autoimmune hepatitis. However, both systems cannot unmask autoimmune hepatitis component efficiently in autoimmune hepatitis patients with concurrent autoimmune or non-autoimmune liver diseases. This study also strongly reiterates the importance of liver biopsy in the work-up of patients. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. | en |
dc.source.uri | <Go to ISI>://WOS:000284516200011 | |
dc.subject | Alcoholic liver disease | en |
dc.subject | Autoimmune hepatitis | en |
dc.subject | International Autoimmune | en |
dc.subject | Hepatitis Group (IAIHG) | en |
dc.subject | Non-alcoholic steatohepatitis | en |
dc.subject | Overalp | en |
dc.subject | syndromes | en |
dc.subject | Primary biliary cirrhosis | en |
dc.subject | Primary sclerosing cholangiitis | en |
dc.subject | Viral hepatitis | en |
dc.subject | PRIMARY BILIARY-CIRRHOSIS | en |
dc.subject | PRIMARY SCLEROSING CHOLANGITIS | en |
dc.subject | CENTRAL | en |
dc.subject | GREECE | en |
dc.subject | LIVER-DISEASE | en |
dc.subject | ANTICARDIOLIPIN ANTIBODIES | en |
dc.subject | OVERLAP SYNDROME | en |
dc.subject | INFECTION | en |
dc.subject | PREVALENCE | en |
dc.subject | CRITERIA | en |
dc.subject | THERAPY | en |
dc.subject | Gastroenterology & Hepatology | en |
dc.title | Comparison of simplified score with the revised original score for the diagnosis of autoimmune hepatitis: A new or a complementary diagnostic score? | en |
dc.type | journalArticle | en |