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dc.creatorFragkou, I. A.en
dc.creatorDagleish, M. P.en
dc.creatorPapaioannou, N.en
dc.creatorCripps, P. J.en
dc.creatorBoscos, C. M.en
dc.creatorVerveridis, H. N.en
dc.creatorOrfanou, D. C.en
dc.creatorSolomakos, N.en
dc.creatorFinlayson, J.en
dc.creatorGovaris, A.en
dc.creatorKyriazakis, I.en
dc.creatorFthenakis, G. C.en
dc.date.accessioned2015-11-23T10:26:45Z
dc.date.available2015-11-23T10:26:45Z
dc.date.issued2010
dc.identifier10.1016/j.tvjl.2009.01.025
dc.identifier.issn1090-0233
dc.identifier.urihttp://hdl.handle.net/11615/27563
dc.description.abstractThe objectives of this study were to investigate the early stages of experimental infection of the ovine mammary gland with Mannheimia haemolytica and to identify the lymphocyte subsets accumulating at the teat duct. M. haemolytica was inoculated into one teat of each of 25 ewes and clinical, bacteriological, cytological, haematological, physicochemical, gross pathological, histopathological and immunohistochemical examinations were carried out. Clinical signs of inflammation were evident by 8 h but had subsided 2 days after challenge. Polymorphonuclear neutrophils (PMN) predominated in milk films up to 1 day following challenge, but the proportion of lymphocytes and macrophages progressively increased thereafter. Total blood leucocyte counts decreased immediately after challenge and then rose until 1 day after challenge with immature PMNs comprising >3% of the total. The pH of the mammary secretions from the challenged side was increased (>7.0). Focal lymphoid accumulations were observed in the lamina propria at the junction of the teat duct and cistern, including CD79(+), CD3(+) and gamma delta T cells, CD68(+) and MHC-II(+) cells with a particular increase in the numbers of CD8(+) T cells from days 3 to 5 after challenge. The findings suggest that these organised lymphoid structures are inducible and contribute to the defence of the infected teat when the PMN-macrophage response is overwhelmed. (C) 2009 Elsevier Ltd. All rights reserved.en
dc.sourceVeterinary Journalen
dc.source.uri<Go to ISI>://WOS:000276878200015
dc.subjectMastitisen
dc.subjectSheepen
dc.subjectTeaten
dc.subjectMannheimia haemolyticaen
dc.subjectImmunohistochemistryen
dc.subjectMAJOR HISTOCOMPATIBILITY COMPLEXen
dc.subjectDELTA-T-CELLSen
dc.subjectSTAPHYLOCOCCUS-AUREUSen
dc.subjectSUBCLINICAL MASTITISen
dc.subjectMAMMARY-GLANDen
dc.subjectBACTERIAL-FLORAen
dc.subjectPASTEURELLA-HAEMOLYTICAen
dc.subjectDEFENSE-MECHANISMSen
dc.subjectINNATE IMMUNITYen
dc.subjectENDen
dc.subjectTISSUESen
dc.subjectVeterinary Sciencesen
dc.titleThe induction of lymphoid follicle-like structures in the ovine teat duct following experimental infection with Mannheimia haemolyticaen
dc.typejournalArticleen


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