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dc.creatorFlouris, A. D.en
dc.creatorMetsios, G. S.en
dc.creatorCarrillo, A. E.en
dc.creatorJamurtas, A. Z.en
dc.creatorGourgoulianis, K.en
dc.creatorKiropoulos, T.en
dc.creatorTzatzarakis, M. N.en
dc.creatorTsatsakis, A. M.en
dc.creatorKoutedakis, Y.en
dc.date.accessioned2015-11-23T10:26:36Z
dc.date.available2015-11-23T10:26:36Z
dc.date.issued2009
dc.identifier10.1164/rccm.200812-1920OC
dc.identifier.issn1073-449X
dc.identifier.urihttp://hdl.handle.net/11615/27492
dc.description.abstractRationale: The acute effect of secondhand smoke (SHS) on lung function and the duration of system disruption remain unknown. Objectives: To assess the SHS effects and their duration on lung function and inflammatory markers. Methods: In a randomized single-blind crossover experiment data were obtained from 16 (8 women) nonsmoking adults at baseline and at 0, 1, and 3 hours after a 1-hour SHS exposure set at bar/restaurant SHIS levels. Measurements and Main Results: Serum and urine cotinine, lung function, and cytokines IL-4, IL-5, IL-6, tumor necrosis factor (TNF)-alpha and IFN-gamma. At 0 hours most lung function parameters were significantly reduced (indicative: FEV(1), 4.3 +/- 0.4 vs. 3.8 +/- 0.3 L; FEV(1),/FVC, 0.9 +/- 0.1 vs. 0.8 +/- 0.1; P < 0.05) but at 3 hours they were at baseline levels. In contrast, cotinine (serum, 8.9 +/- 3.2 vs. 35.5 +/- 10.2 ng.ml(-1)), IL-4 (41.3 +/- 5.8 vs. 44.2 +/- 4.5 pg.ml(-1)), IL-5 (36.1 +/- 3.2 vs. 60.1 +/- 7.0 pg.ml(-1)), IL-6 (2.5 +/- 0.3 vs. 7.6 +/- 1.4 pg.ml(-1)) and IFN-gamma (0.3 +/- 0.2 vs. 0.6 +/- 0.2 IU.ml(-1)) at 3 hours were higher than at baseline (P < 0.05). ILA and TNF-alpha increased only in men, whereas IL-5, IL-6, and IFN-gamma were different between sexes after exposure (P < 0.05). Regression analyses revealed inverse associations of FEV, and FEV,/FVC ratio with IL-5 (P < 0.05) in men and with IL-5 (P = 0.01), IL-6 (P < 0.001), IFN-gamma (P = 0.034) and serum cotinine (P < 0.001) in women. Conclusions: We conclude that I hour of SHIS exposure at bar/restaurant levels is accompanied by significant decrements on lung function and marked increases in inflammatory cytokines, particularly in men. More importantly, whereas most smoke-induced effects on lung function appear to recede within 60 minutes, inflammatory cytokines remain elevated for at least 3 hours after exposure to SHS.en
dc.sourceAmerican Journal of Respiratory and Critical Care Medicineen
dc.source.uri<Go to ISI>://WOS:000266509200011
dc.subjectpassive smokingen
dc.subjectcotinineen
dc.subjectrespirationen
dc.subjectinflammatory markersen
dc.subjectOBSTRUCTIVE PULMONARY-DISEASEen
dc.subjectTHYROID-HORMONE SECRETIONen
dc.subjectHEALTHY-YOUNGen
dc.subjectADULTSen
dc.subjectC-REACTIVE PROTEINen
dc.subjectPASSIVE SMOKINGen
dc.subjectCIGARETTE-SMOKEen
dc.subjectEXPOSUREen
dc.subjectINFLAMMATIONen
dc.subjectTOBACCOen
dc.subjectCOPDen
dc.subjectCritical Care Medicineen
dc.subjectRespiratory Systemen
dc.titleAcute and Short-term Effects of Secondhand Smoke on Lung Function and Cytokine Productionen
dc.typejournalArticleen


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