MECHANISMS OF METAL FUME FEVER AND ITS PROVOCATION BY SELECTED METALS

Abstract

Metal Fume Fever (MFF) is a constellation of influenza-like signs and symptoms, commonly occurring in workers operating galvanizing processes and welders. Its mechanism probably involves cytokine-driven activation of white blood cells. Zinc oxide particles of respirable size suspended in air have been proven to be able to cause the disease. Besides zinc, a significant number of other metals are thought to be able to provoke MFF. The present review analyzes the most probable mechanism hypotheses on MFF. It also appraises the MFF provocation potential of zinc and other metals in terms of validity of case studies and differential diagnosis from similar respiratory diseases.