dc.creator | Eleftheriadis, T. | en |
dc.creator | Sparopoulou, T. | en |
dc.creator | Antoniadi, G. | en |
dc.creator | Liakopoulos, V. | en |
dc.creator | Stefanidis, I. | en |
dc.creator | Galaktidou, G. | en |
dc.date.accessioned | 2015-11-23T10:26:14Z | |
dc.date.available | 2015-11-23T10:26:14Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1560-8115 | |
dc.identifier.uri | http://hdl.handle.net/11615/27345 | |
dc.description.abstract | Background and the purpose of the study: Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immune response. The purpose of this study was to determine the effect of the IDO inhibitor namely 1-methyl-DL-tryptophan (DL-1-MT) on antibody production after vaccination with hepatitis B surface (HBs) antigen. Methods: Four groups of BALB/c mice were immunized with a HBs antigen vaccine. In the first group the vaccine had no DL-1-MT, whereas in the other three groups the vaccine contained 1 mg, 10 mg and 20 mg DL-1-MT. Blood samples were collected 5 weeks post-vaccination and anti-HBs antibodies in the serum were measured by ELISA. Results: Compared to the three groups of mice that were immunized with the vaccines containing DL-1-MT, serum anti-HBs level was much higher in the mice that were immunized with the vaccine with out DL-1-MT. Conclusions: Inhibition of IDO at the time of vaccination decreased humoral immune response to HBs antigen vaccine. The idea that IDO activity is simply immunosuppressive may need to be re-evaluated. | en |
dc.source.uri | <Go to ISI>://WOS:000296992600009 | |
dc.subject | DL-1-MT | en |
dc.subject | IDO | en |
dc.subject | Serum anti-HBs | en |
dc.subject | INDOLEAMINE 2,3-DIOXYGENASE | en |
dc.subject | TRYPTOPHAN CATABOLISM | en |
dc.subject | INDUCTION | en |
dc.subject | TOLERANCE | en |
dc.subject | FOCUS | en |
dc.subject | Pharmacology & Pharmacy | en |
dc.title | Suppression of humoral immune response to hepatitis B surface antigen vaccine in BALB/c mice by 1-methyl-tryptophan co-administration | en |
dc.type | journalArticle | en |