dc.creator | Eleftheriadis, T. | en |
dc.creator | Pissas, G. | en |
dc.creator | Antoniadi, G. | en |
dc.creator | Liakopoulos, V. | en |
dc.creator | Stefanidis, I. | en |
dc.date.accessioned | 2015-11-23T10:26:12Z | |
dc.date.available | 2015-11-23T10:26:12Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1007/s11255-013-0417-z | |
dc.identifier.issn | 0301-1623 | |
dc.identifier.uri | http://hdl.handle.net/11615/27330 | |
dc.description.abstract | Inflammation is common in hemodialysis (HD) patients. Mitochondrial damage-associated molecular patterns (DAMPs) are released during cell necrosis or apoptosis and induce inflammation. Cell apoptosis is increased in HD patients. The mitochondrial protein cytochrome c, as a marker of released mitochondrial DAMPs, and interleukin-6 (IL-6), as a marker of inflammation, were evaluated in HD patients. Thirty-four HD patients and 20 controls were enrolled in the study. Serum cytochrome c and IL-6 were measured by means of enzyme-linked immunosorbent assay. Compared to controls, cytochrome c was markedly increased in HD patients (1392.88 +/- A 905.24 pg/mL vs. 212.95 +/- A 91.71 pg/mL). IL-6 was also significantly increased in HD patients (50.32 +/- A 35.89 pg/mL vs. 14.27 +/- A 6.83 pg/mL). In HD patients serum IL-6 was positively related to serum cytochrome c (r = 0.458). Both circulating cytochrome c and IL-6 are markedly increased in HD patients. Cytochrome c is positively related to IL-6. | en |
dc.source | International Urology and Nephrology | en |
dc.source.uri | <Go to ISI>://WOS:000330345300013 | |
dc.subject | Hemodialysis | en |
dc.subject | Inflammation | en |
dc.subject | Cytochrome c | en |
dc.subject | IL-6 | en |
dc.subject | Mitochondrion | en |
dc.subject | DAMP | en |
dc.subject | CHAIN DOWN-REGULATION | en |
dc.subject | SERUM CYTOCHROME-C | en |
dc.subject | DIALYSIS MEMBRANE | en |
dc.subject | IMMUNE-SYSTEM | en |
dc.subject | IN-VIVO | en |
dc.subject | APOPTOSIS | en |
dc.subject | FAILURE | en |
dc.subject | DNA | en |
dc.subject | PERMEABILITY | en |
dc.subject | INFECTIONS | en |
dc.subject | Urology & Nephrology | en |
dc.title | Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation | en |
dc.type | journalArticle | en |