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Pathogenesis and management of intradialytic hypertension

dc.creatorDousdampanis, P.en
dc.creatorTrigka, K.en
dc.creatorGiannopoulos, A.en
dc.creatorFourtounas, C.en
dc.date.accessioned2015-11-23T10:25:54Z
dc.date.available2015-11-23T10:25:54Z
dc.date.issued2014
dc.identifier.issn15734021
dc.identifier.urihttp://hdl.handle.net/11615/27207
dc.description.abstractHypertension is common in chronic kidney disease patients especially in those undergoing hemodialysis (HD). Usually, blood pressure falls after the HD session but in some patients a paradoxical increase has been observed during or immediately after HD. This phenomenon is referred as intradialytic hypertension. HD patients with intradialytic hypertension or increased blood pressure during HD present higher cardiovascular (CV) morbidity and mortality rates. The underlying mechanism of intradialytic hypertension is multifactorial. Activation both of renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system, volume and sodium overload with concomitant increase in cardiac output, and endothelial dysfunction have been implicated in the pathogenesis of intradialytic hypertension. Given the lack of clinical trials regarding the pathophysiology and management of intradialytic hypertension, current treatment strategies are based mainly on experts’ opinion. The purpose of this review is to describe the pathophysiology of intradialytic hypertension and discuss current strategies in order to improve intradialytic blood pressure management and concomitant HD patients’ outcomes. © 2014 Bentham Science Publishers.en
dc.sourceCurrent Hypertension Reviewsen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84922256424&partnerID=40&md5=e51d4dfa19620d419a78dd8c3a2e90ab
dc.subjectHemodialysisen
dc.subjectIntradialytic hypertensionen
dc.subjectMortalityen
dc.subjectOverhydrationen
dc.subjectPathogenesisen
dc.subjectSodium overloaden
dc.subjectantihypertensive agenten
dc.subjectsodiumen
dc.subjectadrenergic systemen
dc.subjectantihypertensive therapyen
dc.subjectarterial stiffnessen
dc.subjectArticleen
dc.subjectblood pressure measurementen
dc.subjectcardiovascular mortalityen
dc.subjectdisease associationen
dc.subjectendothelial dysfunctionen
dc.subjectextracellular spaceen
dc.subjecthumanen
dc.subjecthypertensionen
dc.subjectoutcome assessmenten
dc.subjectpriority journalen
dc.subjectpulse pressureen
dc.subjectsodium balanceen
dc.subjectsodium blood levelen
dc.subjectsodium restrictionen
dc.subjectsurvivalen
dc.subjectsystemic vascular resistanceen
dc.subjectvascular resistanceen
dc.subjectadverse effectsen
dc.subjectanimalen
dc.subjectautonomic denervationen
dc.subjectblood pressureen
dc.subjectcomplicationen
dc.subjectelectrolyte balanceen
dc.subjectfluid therapyen
dc.subjectinnervationen
dc.subjectkidneyen
dc.subjectKidney Diseasesen
dc.subjectmetabolismen
dc.subjectpathophysiologyen
dc.subjectrenal replacement therapyen
dc.subjectrisk factoren
dc.subjecttreatment outcomeen
dc.subjectAnimalsen
dc.subjectAntihypertensive Agentsen
dc.subjectHumansen
dc.subjectRenal Dialysisen
dc.subjectRisk Factorsen
dc.subjectWater-Electrolyte Balanceen
dc.titlePathogenesis and management of intradialytic hypertensionen
dc.typejournalArticleen


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