Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles
dc.creator | Domali, A. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.creator | Molyvdas, P. A. | en |
dc.date.accessioned | 2015-11-23T10:25:47Z | |
dc.date.available | 2015-11-23T10:25:47Z | |
dc.date.issued | 2000 | |
dc.identifier | 10.1016/S0928-4680(99)00032-2 | |
dc.identifier.issn | 9284680 | |
dc.identifier.uri | http://hdl.handle.net/11615/27153 | |
dc.description.abstract | The objective of the study was to investigate the effect of endothelin-1 (ET-1) on KCl-induced contractions. Tracheal strips were obtained from 12 male rabbits, perfused with Krebs solution and aerated continuously by bubbling with a mixture of 95% O2-5% CO2. Increasing concentrations of ET-1 (10-12-10-7 M) additionally to KCl caused more contractions than KCl-induced (P<0.05). A total of 10-7 M ET-1-induced 14.56% more contraction. Methylene blue (10-5 M) decreased all the contractions induced from simultaneous use of KCl and ET-1. Methylene blue caused about 18% relaxation of contraction induced from KCl (80 mM) and ET-1 (10-8 M). Consequently ET-1 increases the KCl-induced contractions of airway smooth muscles. This effect seem to mediate by a nitric oxide (NO)-guanylate cyclase-cGMP pathway, in which methylene blue is inactivator of guanylate cyclase. Copyright (C) 2000 Elsevier Science Ireland Ltd. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-0034176739&partnerID=40&md5=483a9c124fdc1af4fc12240f063bd956 | |
dc.subject | Airways | en |
dc.subject | Asthma | en |
dc.subject | Channels | en |
dc.subject | Contraction | en |
dc.subject | Endothelin | en |
dc.subject | Physiology | en |
dc.subject | Receptors | en |
dc.subject | cyclic GMP | en |
dc.subject | endothelin 1 | en |
dc.subject | guanylate cyclase | en |
dc.subject | methylene blue | en |
dc.subject | nifedipine | en |
dc.subject | nitric oxide | en |
dc.subject | potassium chloride | en |
dc.subject | animal tissue | en |
dc.subject | article | en |
dc.subject | breathing muscle | en |
dc.subject | concentration response | en |
dc.subject | controlled study | en |
dc.subject | drug antagonism | en |
dc.subject | drug mechanism | en |
dc.subject | drug potentiation | en |
dc.subject | male | en |
dc.subject | nonhuman | en |
dc.subject | priority journal | en |
dc.subject | rabbit | en |
dc.subject | smooth muscle contractility | en |
dc.subject | smooth muscle contraction | en |
dc.subject | smooth muscle relaxation | en |
dc.subject | trachea muscle | en |
dc.title | Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles | en |
dc.type | journalArticle | en |
Fichier(s) constituant ce document
Fichiers | Taille | Format | Vue |
---|---|---|---|
Il n'y a pas de fichiers associés à ce document. |