dc.creator | Danielides, S. | en |
dc.creator | Mavragani, C. P. | en |
dc.creator | Katsakoulas, I. | en |
dc.creator | Zintzaras, E. | en |
dc.creator | Drosos, A. A. | en |
dc.creator | Vlachoyiannopoulos, P. G. | en |
dc.creator | Moutsopoulos, H. M. | en |
dc.date.accessioned | 2015-11-23T10:25:06Z | |
dc.date.available | 2015-11-23T10:25:06Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.3109/03009742.2010.549837 | |
dc.identifier.issn | 0300-9742 | |
dc.identifier.uri | http://hdl.handle.net/11615/26880 | |
dc.description.abstract | Objectives: Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes. Methods: A total of 138 patients with SSc [46 with diffuse (dSSc) and 92 with limited scleroderma (lSSc)] and 100 healthy controls (HC) were tested for the presence of ATA [anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies] using a commercial enzyme-linked immunosorbent assay (ELISA). Clinical and serological data were recorded. Results: An increased prevalence of anti-TPO but not anti-Tg antibodies was detected in patients with SSc compared to HC (27.5% vs. 14%, p = 0.016). Of note, a statistically significant increase of anti-TPO was detected only in patients with lSSc compared to HC (32.6% vs. 14%, p = 0.003). No correlations with other clinical features were detected. Conclusions: An increased prevalence of anti-TPO antibodies was identified in patients with lSSc. We propose that ATA testing should be offered to this subgroup of patients. | en |
dc.source | Scandinavian Journal of Rheumatology | en |
dc.source.uri | <Go to ISI>://WOS:000294068000009 | |
dc.subject | PROGRESSIVE SYSTEMIC-SCLEROSIS | en |
dc.subject | THYROID AUTOANTIBODIES | en |
dc.subject | RHEUMATOID-ARTHRITIS | en |
dc.subject | AUTOIMMUNE-DISEASES | en |
dc.subject | LUPUS-ERYTHEMATOSUS | en |
dc.subject | SJOGRENS-SYNDROME | en |
dc.subject | HYPOTHYROIDISM | en |
dc.subject | POLYAUTOIMMUNITY | en |
dc.subject | ATHEROSCLEROSIS | en |
dc.subject | DYSFUNCTION | en |
dc.subject | Rheumatology | en |
dc.title | Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma | en |
dc.type | journalArticle | en |