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Cumulative pregnancy rate after ICSI with cryopreserved testicular tissue in non-obstructive azoospermia

dc.creatorDafopoulos, K.en
dc.creatorGriesinger, G.en
dc.creatorSchultze-Mosgau, A.en
dc.creatorOrief, Y.en
dc.creatorSchöpper, B.en
dc.creatorNikolettos, N.en
dc.creatorDiedrich, K.en
dc.creatorAl-Hasani, S.en
dc.date.accessioned2015-11-23T10:24:55Z
dc.date.available2015-11-23T10:24:55Z
dc.date.issued2005
dc.identifier.issn14726483
dc.identifier.urihttp://hdl.handle.net/11615/26790
dc.description.abstractThe aim of the present study was to describe a simplified and inexpensive method of testicular tissue freezing to assess the cumulative clinical pregnancy rate (CPR) by this technique, and to provide useful information for counselling couple with non-obstructive azoospermia. One hundred and sixty-five couples with non-obstructive azoospermic males pursuing assisted conception, from December 1995 to December 2002, were included. In all cases, the testicular tissue retrieved by open multiple-biopsy (both sides, by testicular sperm extraction) was frozen using a simple liquid nitrogen vapour freezing technique and was stored in liquid nitrogen thereafter. Only mature spermatozoa were used for intracytoplasmic sperm injection (ICSI) after thawing. Expected CPR were calculated using the Kaplan-Meier survival analysis. A total of 281 cycles were performed resulting in 53 clinical pregnancies. Crude and expected CPR (95% confidence intervals) after three cycles were 32.1 (25.7-40.1) and 55.7% (37.0-74.4) respectively. In conclusion, this simplified method for freezing testicular tissue resulted in a satisfactory outcome after ICSI in cases of non-obstructive azoospermia.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-16844380157&partnerID=40&md5=eedcc2ec0cc8692944ff6033d86516b9
dc.subjectCryopreservationen
dc.subjectCumulative clinical pregnancy rateen
dc.subjectICSIen
dc.subjectNon-obstructive azoospermiaen
dc.subjectTESEen
dc.subjectcetrorelixen
dc.subjectchorionic gonadotropinen
dc.subjectganirelixen
dc.subjectgonadorelin agonisten
dc.subjecthuman menopausal gonadotropinen
dc.subjectleuprorelinen
dc.subjectliquid nitrogenen
dc.subjectprogesteroneen
dc.subjectrecombinant chorionic gonadotropinen
dc.subjectrecombinant follitropinen
dc.subjecttriptorelinen
dc.subjectutrogesten
dc.subjectadulten
dc.subjectarticleen
dc.subjectazoospermiaen
dc.subjectcell maturationen
dc.subjectcell survivalen
dc.subjectcell viabilityen
dc.subjectfemaleen
dc.subjectfreeze thawingen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjectintracytoplasmic sperm injectionen
dc.subjectKaplan Meier methoden
dc.subjectkaryotypeen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmarital therapyen
dc.subjectmethodologyen
dc.subjectovulation inductionen
dc.subjectpregnancy rateen
dc.subjectsperm preservationen
dc.subjectspermatogenesisen
dc.subjectspermatozoonen
dc.subjecttesticular sperm extractionen
dc.subjecttestis biopsyen
dc.subjecttreatment outcomeen
dc.subjectEquipment Designen
dc.subjectHumansen
dc.subjectOligospermiaen
dc.subjectPregnancyen
dc.subjectSperm Injections, Intracytoplasmicen
dc.subjectSurvival Analysisen
dc.subjectTestisen
dc.titleCumulative pregnancy rate after ICSI with cryopreserved testicular tissue in non-obstructive azoospermiaen
dc.typejournalArticleen


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