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dc.creatorDafopoulos, K.en
dc.creatorGriesinger, G.en
dc.creatorSchultze-Mosgau, A.en
dc.creatorOrief, Y.en
dc.creatorSchöpper, B.en
dc.creatorNikolettos, N.en
dc.creatorDiedrich, K.en
dc.creatorAl-Hasani, S.en
dc.date.accessioned2015-11-23T10:24:55Z
dc.date.available2015-11-23T10:24:55Z
dc.date.issued2005
dc.identifier.issn14726483
dc.identifier.urihttp://hdl.handle.net/11615/26789
dc.description.abstractThere is a lack of data regarding variables affecting the treatment outcome for non-obsructive azoospermia when spermatozoa from cryopreserved testicular specimens are utilized for ICSI. The objective of the present retrospective analysis was to investigate the effect of various parameters on treatment outcome it such cases. One hundred and sixty-five couples with non-obstructive azoospermic males undergoing a total of 297 cycles were included. In all cases the testicular tissue retrieved by multiple open-biopsy testicular sperm extraction was stored in liquid nitrogen and, after thawing, only, mature spermatozoa were used for ICSI. When no motile spermatozoa were recovered, immotile spermatoa were used. In 159 cycles, motile spermatozoa were utilized for ICSI, while in 138 cycles immotile spermatozoa were utilized. Higher normal fertilization rate (60.4. ± 3.1 versus 51.3 ± 1.6%, P < 0.05), number of emberyos transffered (2.8 ± 0.06 versus 2.6 ± 0.04, P < 0.05), modified cumulative embryo score (31.2 ± 2.6 versus 0.04, P < 0.05), modified cumulative embryo score 31.2 ± 2.6% ± spermatozoa injected (67.8 versus 49.8%, P < 0.05) were observed in cycles that resulted in clinical pregnancies. Binary logistic regression analysis showed that sperm motility (odds ratio 2.06, 95% CI 1.1-3.9, P < 0.05), but not woman's age, number of treatment cycle, type of GnRH-analogue used for pituitary suppression, number of oocytes retrieved or number of embryos transferred was a significant determinant of the likelihood of clinical pregnancy. It conclusion, sperm motility after freeze/thawing of testicular tissue is the major determinant of the success of ICSI in non-obstructive azoospermia.en
dc.sourceReproductive BioMedicine Onlineen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-16844385557&partnerID=40&md5=ed117030a7da866337520744d19c58a9
dc.subjectICSIen
dc.subjectNon-obstructive azoospermiaen
dc.subjectSperm motilityen
dc.subjectTESEen
dc.subjectcetrorelixen
dc.subjectchorionic gonadotropinen
dc.subjectgonadorelinen
dc.subjectgonadorelin agonisten
dc.subjectgonadotropinen
dc.subjectleuprorelinen
dc.subjectliquid nitrogenen
dc.subjectmenegonen
dc.subjectprogesteroneen
dc.subjectrecombinant follitropinen
dc.subjectutrogesten
dc.subjectadulten
dc.subjectarticleen
dc.subjectazoospermiaen
dc.subjectcell maturationen
dc.subjectcell viabilityen
dc.subjectcryopreservationen
dc.subjectembryo transferen
dc.subjectfemaleen
dc.subjectfertilizationen
dc.subjectfetus heart rateen
dc.subjectfreeze thawingen
dc.subjecthumanen
dc.subjecthuman tissueen
dc.subjectintracytoplasmic sperm injectionen
dc.subjectkaryotypeen
dc.subjectlogistic regression analysisen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectovulation inductionen
dc.subjectpregnancy rateen
dc.subjectretrospective studyen
dc.subjectrisk factoren
dc.subjectsperm donoren
dc.subjectsperm preservationen
dc.subjectspermatozoonen
dc.subjectspermatozoon motilityen
dc.subjecttestis biopsyen
dc.subjecttransvaginal echographyen
dc.subjecttreatment outcomeen
dc.subjectHumansen
dc.subjectLogistic Modelsen
dc.subjectOligospermiaen
dc.subjectPregnancyen
dc.subjectRetrospective Studiesen
dc.subjectSperm Injections, Intracytoplasmicen
dc.subjectSpermatozoaen
dc.subjectTestisen
dc.subjectTissue and Organ Harvestingen
dc.titleFactors affecting outcome after ICSI with spermatozoa retrieved from cryopreserved testicular tissue in non-obstructive azoospermiaen
dc.typejournalArticleen


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