Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
dc.creator | Clarimon, J. | en |
dc.creator | Xiromerisiou, G. | en |
dc.creator | Eerola, J. | en |
dc.creator | Gourbali, V. | en |
dc.creator | Hellstrom, O. | en |
dc.creator | Dardiotis, E. | en |
dc.creator | Peuralinna, T. | en |
dc.creator | Papadimitriou, A. | en |
dc.creator | Hadjigeorgiou, G. M. | en |
dc.creator | Tienari, P. J. | en |
dc.creator | Singleton, A. B. | en |
dc.date.accessioned | 2015-11-23T10:24:48Z | |
dc.date.available | 2015-11-23T10:24:48Z | |
dc.date.issued | 2005 | |
dc.identifier | 10.1186/1471-2377-5-11 | |
dc.identifier.issn | 1471-2377 | |
dc.identifier.uri | http://hdl.handle.net/11615/26729 | |
dc.description.abstract | Background: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods: Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results: No association was found in any of the populations studied. Conclusion: Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. | en |
dc.source.uri | <Go to ISI>://WOS:000236187900001 | |
dc.subject | FAMILIAL AGGREGATION | en |
dc.subject | CLONING | en |
dc.subject | Clinical Neurology | en |
dc.title | Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients | en |
dc.type | journalArticle | en |
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