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Alterations of microRNAs in solid cancers and their prognostic value

dc.creatorChira, P.en
dc.creatorVareli, K.en
dc.creatorSainis, I.en
dc.creatorPapandreou, C.en
dc.creatorBriasoulis, E.en
dc.date.accessioned2015-11-23T10:24:39Z
dc.date.available2015-11-23T10:24:39Z
dc.date.issued2010
dc.identifier10.3390/cancers2021328
dc.identifier.issn20726694
dc.identifier.urihttp://hdl.handle.net/11615/26647
dc.description.abstractMicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Each miRNA represses the protein expression of several coding genes in a manner proportional to the sequence complementarity with the target transcripts. MicroRNAs play key regulatory roles in organismal development and homeostasis. They control fundamental biological processes, such as stem-cell regulation and cellular metabolism, proliferation, differentiation, stress resistance, and apoptosis. Differential miRNA expression is found in malignant tumors in comparison to normal tissue counterparts. This indicates that miRNA deregulation contributes to the initiation and progression of cancer. Currently, miRNA expression signatures are being rigorously investigated in various tumor types, with the aim of developing novel, efficient biomarkers that can improve clinical management of cancer patients. This review discusses deregulated miRNAs in solid tumors, and focuses on their emerging prognostic potential. © 2010 by the authors; licensee MDPI, Basel, Switzerland.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-79952269661&partnerID=40&md5=4bd6edf2eae438bd701fe6f7ecf99a3a
dc.subjectCanceren
dc.subjectGene-silencingen
dc.subjectmicroRNAen
dc.subjectNegative-regulationen
dc.subjectPrognostic biomarkersen
dc.subjectSolid tumorsen
dc.subjectapoptosisen
dc.subjectbladder canceren
dc.subjectbreast canceren
dc.subjectcancer growthen
dc.subjectcancer researchen
dc.subjectcancer susceptibilityen
dc.subjectcarcinogenesisen
dc.subjectcell differentiationen
dc.subjectcell metabolismen
dc.subjectcell proliferationen
dc.subjectcell stressen
dc.subjectcentral nervous system tumoren
dc.subjectcolorectal canceren
dc.subjectgene expression profilingen
dc.subjectgene expression regulationen
dc.subjectgene functionen
dc.subjectgene overexpressionen
dc.subjectgenetic conservationen
dc.subjectgerm cell tumoren
dc.subjecthead and neck canceren
dc.subjecthumanen
dc.subjecthypophysis adenomaen
dc.subjectkidney canceren
dc.subjectliver cell carcinomaen
dc.subjectlung canceren
dc.subjectmelanomaen
dc.subjectmetabolic regulationen
dc.subjectmouth carcinomaen
dc.subjectnonhumanen
dc.subjectosteosarcomaen
dc.subjectovary canceren
dc.subjectpancreas canceren
dc.subjectprognosisen
dc.subjectprostate canceren
dc.subjectprotein expressionen
dc.subjectreviewen
dc.subjectRNA metabolismen
dc.subjectsarcomaen
dc.subjectsignal transductionen
dc.subjectsingle nucleotide polymorphismen
dc.subjectskin canceren
dc.subjectsoft tissue sarcomaen
dc.subjectsolid tumoren
dc.subjectsquamous cell carcinomaen
dc.subjectstem cellen
dc.subjectstomach canceren
dc.subjectthyroid canceren
dc.titleAlterations of microRNAs in solid cancers and their prognostic valueen
dc.typejournalArticleen


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