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The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis

dc.creatorBraliou, G. G.en
dc.creatorGrigoriadou, A. M. G.en
dc.creatorKontou, P. I.en
dc.creatorBagos, P. G.en
dc.date.accessioned2015-11-23T10:24:11Z
dc.date.available2015-11-23T10:24:11Z
dc.date.issued2014
dc.identifier10.1016/j.csbj.2014.05.006
dc.identifier.issn20010370
dc.identifier.urihttp://hdl.handle.net/11615/26447
dc.description.abstractRenal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the association of the A1166C polymorphism of Angiotensin II type 1 Receptor gene (AGTR1) with Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), IgA Nephropathy (IgAN) and Vesicoureteral Reflux (VUR) as well as the association of A1332G polymorphism of Angiotensin II type 2 Receptor (AGTR2) gene with Vesicoureteral Reflux (VUR). We found that neither AGTR1 A1166C, nor AGTR2 A1332G polymorphisms were significantly associated with any of the aforementioned renal diseases, suggesting that they cannot be used as predictive markers in either general or subgroup ethnic populations. © 2014 Braliou et al.en
dc.sourceComputational and Structural Biotechnology Journalen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84907385763&partnerID=40&md5=e29e66aadaf8afdeb953eca09cfcfee2
dc.subjectAngiotensin receptoren
dc.subjectCKDen
dc.subjectESRDen
dc.subjectGenetic associationen
dc.subjectKidney diseaseen
dc.subjectPolymorphismen
dc.subjectangiotensin 1 receptoren
dc.subjectangiotensin 2 receptoren
dc.subjectalleleen
dc.subjectangiotensin 1 receptor geneen
dc.subjectangiotensin 2 receptor geneen
dc.subjectArticleen
dc.subjectchronic kidney diseaseen
dc.subjectend stage renal diseaseen
dc.subjectethnic groupen
dc.subjectgenetic markeren
dc.subjectgenotypeen
dc.subjectglomerulonephritisen
dc.subjecthemodialysisen
dc.subjecthumanen
dc.subjectimmunoglobulin A nephropathyen
dc.subjectinterstitial nephritisen
dc.subjectkidney transplantationen
dc.subjectperitoneal dialysisen
dc.subjectphenotypeen
dc.subjectpredictive valueen
dc.subjectpriority journalen
dc.subjectreceptor geneen
dc.subjectrenin angiotensin aldosterone systemen
dc.subjectrenin angiotensin disorderen
dc.subjectsingle nucleotide polymorphismen
dc.subjectsystematic reviewen
dc.subjectvesicoureteral refluxen
dc.titleThe role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysisen
dc.typejournalArticleen


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