Daptomycin use in patients with osteomyelitis: A preliminary report from the EU-CORESM database
dc.creator | Andrew Seaton, R. | en |
dc.creator | Malizos, K. N. | en |
dc.creator | Viale, P. | en |
dc.creator | Gargalianos-Kakolyris, P. | en |
dc.creator | Santantonio, T. | en |
dc.creator | Petrelli, E. | en |
dc.creator | Pathan, R. | en |
dc.creator | Heep, M. | en |
dc.creator | Chaves, R. L. | en |
dc.date.accessioned | 2015-11-23T10:22:20Z | |
dc.date.available | 2015-11-23T10:22:20Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1093/jac/dkt067 | |
dc.identifier.issn | 3057453 | |
dc.identifier.uri | http://hdl.handle.net/11615/25594 | |
dc.description.abstract | Background: Osteomyelitis is a complex and heterogeneous group of infections that require surgical and antimicrobial interventions. Because treatment failure or intolerance is common, new treatment options are needed. Daptomycin has broad Gram-positive activity, penetrates bone effectively and has bactericidal activity within biofilms. This is the first report on clinical outcomes in patients with osteomyelitis from the multicentre, retrospective, non-interventional European Cubicin® Outcomes Registry and Experience (EU-CORESM), a large database on real-world daptomycin use. Patients and methods: In total, 220 patients were treated for osteomyelitis; the population was predominantly elderly, with predisposing baseline conditions such as diabetes and chronic renal/cardiac diseases. Results: Most patients (76%) received prior antibiotic treatment, and first-line treatment failure was the most frequent reason to start daptomycin. Common sites of infection were the knee (22%) or hip (21%), and the most frequently isolated pathogens were Staphylococcus aureus (33%) and coagulase-negative staphylococci (32%). Overall, 52% of patients had surgery, 55% received concomitant antibiotics and 29% received a proportion of daptomycin therapy as outpatients. Clinical success was achieved in 75% of patients. Among patients with prosthetic device-related osteomyelitis, there was a trend towards higher success rates if the device was removed. Daptomycin was generally well tolerated. Conclusions: This analysis suggests that daptomycin is an effective and well-tolerated treatment option for osteomyelitis and highlights the importance of optimal surgical intervention and appropriate microbiological diagnosis for clinical outcomes. | en |
dc.source | Journal of Antimicrobial Chemotherapy | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84879472754&partnerID=40&md5=e694ffff1fbde34d763f92d4d387acb7 | |
dc.subject | Bone infections | en |
dc.subject | Gram-positive infections | en |
dc.subject | Lipopeptides | en |
dc.subject | Non-interventional study | en |
dc.subject | Prosthetic device infections | en |
dc.subject | daptomycin | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | antibiotic therapy | en |
dc.subject | article | en |
dc.subject | chronic kidney disease | en |
dc.subject | coxitis | en |
dc.subject | diabetes mellitus | en |
dc.subject | drug efficacy | en |
dc.subject | drug safety | en |
dc.subject | drug tolerability | en |
dc.subject | female | en |
dc.subject | heart disease | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | osteomyelitis | en |
dc.subject | population research | en |
dc.subject | prosthesis infection | en |
dc.subject | retrospective study | en |
dc.subject | Staphylococcus infection | en |
dc.subject | treatment failure | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Anti-Bacterial Agents | en |
dc.subject | Gram-Positive Bacteria | en |
dc.subject | Gram-Positive Bacterial Infections | en |
dc.subject | Humans | en |
dc.subject | Middle Aged | en |
dc.subject | Retrospective Studies | en |
dc.subject | Treatment Outcome | en |
dc.title | Daptomycin use in patients with osteomyelitis: A preliminary report from the EU-CORESM database | en |
dc.type | journalArticle | en |
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