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SAFB1 interacts with and suppresses the transcriptional activity of p53
(2011)
A significant amount of nuclear p53 is found associated with the nuclear matrix in cells that were exposed to genotoxic stress. In this study we identified Scaffold attachment factor B1 (SAFB1), a nuclear matrix-associated ...
HMMpTM: Improving transmembrane protein topology prediction using phosphorylation and glycosylation site prediction
(2014)
During the last two decades a large number of Computational methods have been developed for predicting transmembrane protein topology. Current predictors rely on topogenic signals in the protein sequence, such as the ...
Computer simulation based selection of optimal monomer for imprinting of tri-O-acetiladenosine in polymer matrix: vacuum calculations
(2013)
Molecularly imprinted polymers can be anticipated as synthetic imitation of natural antibodies, receptors and enzymes. In case of successful imprinting the selectivity and affinity of the imprint for substrate molecules ...
hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies
(2012)
Human coilin interacting nuclear ATPase protein (hCINAP) directly interacts with coilin, a marker protein of Cajal Bodies (CBs), nuclear organelles involved in the maturation of small nuclear ribonucleoproteins UsnRNPs and ...
Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera
(2013)
Hepcidin, a hepatic hormone, regulates serum iron levels by controlling both intestinal iron absorption and iron release from macrophages. Although transcription of hepcidin is controlled by diverse stimuli, it remains ...
Effects of the Val211Gly substitution on molecular dynamics of the CMY-2 cephalosporinase: Implications on hydrolysis of expanded-spectrum cephalosporins
(2011)
CMY-30, a naturally occurring class C beta-lactamase differing from the Citrobacter freundii-derived CMY-2 by a Val211Gly substitution in the X-loop, exhibits increased hydrolytic efficiency against ceftazidime and cefotaxime. ...
Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b
(2015)
We present a study on the binding of gallic acid and its dimer ellagic acid to glycogen phosphorylase (GP). Ellagic acid is a potent inhibitor with K(i)s of 13.4 and 7.5 mu M, in contrast to gallic acid which displays K(i)s ...
Passive smoking reduces and vitamin C increases exercise-induced oxidative stress: Does this make passive smoking an anti-oxidant and vitamin C a pro-oxidant stimulus?
(2014)
The current interpretative framework states that, for a certain experimental treatment (usually a chemical substance) to be classified as "anti-oxidant", it must possess the property of reducing (or even nullifying) ...
Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via beta-catenin upregulation
(2013)
Osteoarthritis (OA) is a debilitating disease of the joints characterized by cartilage degradation but to date there is no available pharmacological treatment to inhibit disease progression neither is there any available ...
Building arks for tRNA: Structure and function of the Arc1p family of non-catalytic tRNA-binding proteins
(2010)
Following the intricate architecture of the eukaryotic cell, protein synthesis involves formation of many macromolecular assemblies, some of which are composed by tRNA-aminoacylation enzymes. Protein-protein and protein-tRNA ...