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Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4 alpha
(2004)
Hepatocyte nuclear factor-4alpha (HNF-4alpha), a member of the nuclear receptor superfamily, is a crucial regulator of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism. Unlike other members ...
Variation in sulfation pattern containing proteoglycans development of uterine of galactosaminoglycan is associated with the leiomyoma
(2004)
The variations in sulfation patterns of glycosaminoglycans (GAGs) present in human normal myometrium, and uterine leiomyoma were characterized following specific enzymic treatments and analysis by high-performance capillary ...
Recombination in primeval genomes: A step forward but still a long leap from maintaining a sizable genome
(2004)
A stubborn question in early molecular evolution is how to sustain the "minimum" informational length required for the basic features of life with a putative low-copying fidelity RNA polymerase ribozyme. Proposals to ...
Mitochondrial DNA variation in northeast atlantic and mediterranean populations of norway lobster, Nephrops norvegicus
(2004)
Analysis of the genetic structure of the Norway lobster (Nephrops norvegicus), a marine crustacean with high commercial value, was undertaken to gain information regarding the differentiation of Atlantic from Mediterranean ...
Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
(2004)
Cobalt can mimic hypoxia and has been implicated as a cause of lung defects. However, the effect of cobalt on airway smooth muscle (ASM) cells has not been analyzed in detail. In this article, we use primary cultures of ...
Molecular identification of enteroviruses responsible for an outbreak of aseptic meningitis; implications in clinical practice and epidemiology
(2004)
An outbreak of aseptic meningitis was recorded in Greece during the year 2001. Detection of the clinical strains was achieved by performing reverse transcription-polymerase chain reaction (RT-PCR) on RNA isolated from cell ...
Amplification of Echoviruses genomic regions by different RT-PCR protocols - a comparative study
(2004)
In the present report, the results of a comparative study in the detection of all Echoviruses reference strains as well as of 38 clinical isolates are presented. Using RT-PCR with already published primer pairs (UG(52)-UC53, ...
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin
(2004)
The enzymes aldehyde oxidase and xanthine oxidase catalyze the oxidation of a wide range of N-heterocycles and aldehydes. These enzymes are widely known for their role in the metabolism of N-heterocyclic xenobiotics where ...