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Protein misfolding in neurodegenerative diseases
(2004)
A common pathogenic mechanism shared by diverse neurodegenerative disorders, like Alzheimer's disease, Parkinson's disease, Huntington's disease and transmissible spongiform encephalopathies, may be altered protein homeostasis ...
Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: a meta-analysis
(2004)
Paraoxonase1 (PON1) gene polymorphisms were implicated as risk factors for Parkinson's disease (PD), but the results of case-control studies that investigated these associations were controversial. In order to provide an ...
A new mitochondrial DNA mutation in ND3 gene causing severe Leigh syndrome with early lethality
(2004)
We describe a new mitochondrial DNA mutation in a male infant who presented clinical and magnetic resonance imaging features of Leigh syndrome and died at the age of 9 mo. The patient's development was reportedly normal ...
Motor signs during the course of Alzheimer disease
(2004)
Background: Motor signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline, mortality, and cost of care. Objective: To describe the progression and identify predictors of ...