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Polycystic ovaries and obesity
(2015)
Almost 50% of the women with polycystic ovary syndrome (PCOS) are obese. Obesity in PCOS affects reproduction via various mechanisms. Hyperandrogenism, increased luteinizing hormone (LH) and insulin resistance play a pivotal ...
Novel aspects of the endocrinology of the menstrual cycle
(2014)
Ovarian control of gonadotrophin secretion is normally achieved via the feedback mechanisms mediated by oestradiol and progesterone. Evidence has been provided that nonsteroidal substances, such as inhibin A and B, participate ...
Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone
(2011)
Objectives: It has been suggested that inhibin secretion is altered in women with the polycystic ovary syndrome (PCOS). However, the contribution of a preceding luteal phase has not been taken into account. The aim of the ...
The progesterone positive feedback effect in women after ovariectomy
(2013)
Various ovarian substances regulate the secretion of gonadotrophins during the menstrual cycle, but there are still several unclarified issues. The aim of this study was to investigate the positive feedback effect of ...
Ghrelin: New Insights into Female Reproductive System-Associated Disorders and Pregnancy
(2012)
Ghrelin is considered the endogenous ligand of growth hormone secretagogue receptor type 1a, and its modulatory actions have been demonstrated in a large array of endocrine and nonendocrine functions. According to recent ...
Attenuating activity of the ovary on LH response to GnRH during the follicular phase of the cycle
(2014)
Objective Oestradiol sensitizes the pituitary to GnRH, while gonadotrophin surge attenuating factor (GnSAF) may oppose this action. Using the LH response to GnRH during treatment with FSH as an in vivo bioassay for GnSAF, ...
Attenuation of the oestrogen positive feedback mechanism with the age in postmenopausal women
(2015)
ObjectiveIt has been reported that the positive feedback mechanism of oestrogens and progesterone is preserved, although attenuated, in late postmenopausal years. Whether this is also true for the positive feedback effect ...