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Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility

Jiang, Q.; Shi, D.; Nakajima, M.; Dai, J.; Wei, J.; Malizos, K. N.; Qin, J.; Miyamoto, Y.; Kamatani, N.; Liu, B.; Tsezou, A.; Nakamura, T.; Ikegawa, S. (2008)

A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the ...

Lower fibroblast growth factor 23 levels in young adults with crohn disease as a possible secondary compensatory effect on the disturbance of bone and mineral metabolism

Oikonomou, K. A.; Orfanidou, T. I.; Vlychou, M. K.; Kapsoritakis, A. N.; Tsezou, A.; Malizos, K. N.; Potamianos, S. P. (2014)

Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal ...

Gilbert Syndrome as a Predisposing Factor for Cholelithiasis Risk in the Greek Adult Population

Tsezou, A.; Tzetis, M.; Giannatou, E.; Spanos, I.; Roma, E.; Fretzayas, A.; Kanavakis, E.; Kitsiou-Tzeli, S. (2009)

We investigated the hypothesis that coinheritance of the common A(TA)(n)TAA promoter mutation at the UGT1A1 locus associated with Gilbert syndrome is a risk factor for gallstone formation in a homogeneous adult population, ...

1,25-Dihydroxyvitamin D-3 and extracellular inorganic phosphate activate mitogen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in osteoarthritic chondrocytes

Orfanidou, T.; Malizos, K. N.; Varitimidis, S.; Tsezou, A. (2012)

Hypertrophy and impaired mineralization are two processes closely associated with osteoarthritis (OA). 1,25-dihydroxyvitamin D-3 (1a,25(OH)(2)D-3) and inorganic phosphate (Pi) are two important factors that are implicated ...

Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men

Karatzas, A.; Giannatou, E.; Tzortzis, V.; Gravas, S.; Aravantinos, E.; Moutzouris, G.; Melekos, M.; Tsezou, A. (2010)

Background: Catechol-estrogen metabolites can induce carcinogenesis by acting as endogenous tumor initiators. Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is a main metabolic pathway ...

Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes

Papanikolaou, V.; Stefanou, N.; Dubos, S.; Papathanasiou, I.; Palianopoulou, M.; Valiakou, V.; Tsezou, A. (2015)

Tamoxifen is a major treatment modality for estrogen receptor positive breast cancer, but the occurrence of resistance remains a problem. Recently, obesity-related leptin has been found to interfere with tamoxifen in breast ...

NEW FUNCTIONAL MICROSATELLITE ASSOCIATED WITH OSTEOARTHRITIS SUSCEPTIBILITY

Vidal-Bralo, L.; Rodriguez-Fontela, C.; Calaza, M.; Oreiro, N.; Blanco, F. J.; Carr, A.; Odriozola, A.; Riancho, J.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A.; arc, Ogen Consortium (2014)

The involvement of HER2 and p53 status in the regulation of telomerase in irradiated breast cancer cells

Papanikolaou, V.; Iliopoulos, D.; Dimou, I.; Dubos, S.; Tsougos, I.; Theodorou, K.; Kitsiou-Tzeli, S.; Tsezou, A. (2009)

Cancer cell characteristics may play a pivotal role in the response to therapy by activating or deactivating different molecular pathways. In the present study, we investigated the implication of breast cancer cell features, ...

The Catabolic Role of Toll-Like Receptor 2 (TLR-2) Mediated by the NF-kappa B Pathway in Septic Arthritis

Papathanasiou, I.; Malizos, K. N.; Poultsides, L.; Karachalios, T.; Oikonomou, P.; Tsezou, A. (2011)

Toll-like receptors (TLRs) are involved in mediating cell activation on stimulation with microbial components. Our objective was to investigate the role of 'PLR-2 mediated by the NF-kappa B pathway in septic arthritic ...

THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS

Panoutsopoulou, K.; Southam, L.; Rayner, W.; Zhai, G.; Beazley, C.; Arden, N.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Olher, W.; Ralston, S.; Spector, T.; Valdes, A.; Wallis, G.; Wilkinson, M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.; Bumpstead, S.; Cupples, A.; Day-Williams, A.; Dixon, K.; Dohertys, S.; Elliott, K.; Evangelou, E.; Felson, D.; Gomez-Reino, J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Hofman, A.; Hunt, S.; Ioannidis, J.; Jonsdottir, I.; Keen, R.; Kerkhof, H.; Kloppenburg, M.; Koller, N.; Lakenberg, N.; Lane, N.; Lee, A.; Meulenbelt, I.; Nevitt, M.; O'Neill, F.; Parimi, N.; Potter, S.; Rego-Perez, I.; Riancho, J.; Sherburn, K.; Slagboom, E.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Tsezou, A.; Uitterlinden, A.; van Meurs, J.; Watkins, B.; Wheeler, M.; Mitchelle, S.; Zhu, Y.; Zmuda, J.; Zeggini, E.; Loughlin, J.; Arc, Ogen Consortium (2010)

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