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Αποτελέσματα 31-40 από 1846
Ticagrelor and prasugrel: Two novel, most-promising antiplatelet agents
(2010)
The need for safe and effective antiplatelet agents motivates scientists towards a non-ceasing research which has through the past few years provided patients suffering from coronary artery disease, submitted or not to ...
Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory t-cell differentiation in alloreactive human lymphocytes
(2013)
Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits aerobic glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also ...
Investigation of physicians' attitudes concerning the implementation of international classification systems of diseases as a precondition for evidence-based policy making
(2013)
This study investigated the main factors affecting physicians' attitudes toward the implementation of international classification systems of diseases. A cross-sectional study was carried out during September 2010. The ...
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration
(2011)
Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be ...
HIF-1α in colorectal carcinoma: Review of the literature
(2015)
Colorectal cancer (CRC) is the third most common cancer worldwide and despite the abundance of molecular pathways and markers continually being reported, the mortality rates remain high. Hypoxia inducible f actor lalpha ...
Daptomycin use in patients with osteomyelitis: A preliminary report from the EU-CORESM database
(2013)
Background: Osteomyelitis is a complex and heterogeneous group of infections that require surgical and antimicrobial interventions. Because treatment failure or intolerance is common, new treatment options are needed. ...
Verbal fluency in adults diagnosed with attention-deficit hyperactivity disorder (ADHD) in childhood
(2013)
It has been increasingly believed that attention-deficit hyperactivity disorder (ADHD) is a disorder with lifelong course associated with cognitive difficulties including among others, language production, verbal learning, ...
Hereditary hyperferritinemia cataract syndrome as a cause of childhood hyperferritinemia
(2014)
A 2-year-old female was presented with high levels of serum ferritin (890 ng/mL) in a routine blood test. Clinical and laboratory investigations excluded the presence of iron overload and secondary causes of hyperferritinemia. ...
Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach
(2010)
To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). ...