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Genetic basis of Parkinson disease

Xiromerisiou, G.; Dardiotis, E.; Tsimourtou, V.; Kountra, P. M.; Paterakis, K. N.; Kapsalaki, E. Z.; Fountas, K. N.; Hadjigeorgiou, G. M. (2010)

Over the past few years, considerable progress has been made in understanding the molecular mechanisms of Parkinson disease (PD). Mutations in certain genes are found to cause monogenic forms of the disorder, with autosomal ...

Lack of Association of the UCHL-1 Gene with Parkinson's Disease in a Greek Cohort: A Haplotype-Tagging Approach

Xiromerisiou, G.; Kyratzi, E.; Dardiotis, E.; Bozi, M.; Tsimourtou, V.; Stamboulis, E.; Ralli, S.; Vassilatis, D.; Gourbali, V.; Kountra, P. M.; Fountas, K.; Papadimitriou, A.; Stefanis, L.; Hadjigeorgiou, G. M. (2011)

Association Between the Interleukin-1 beta Gene (IL1B) C-511T Polymorphism and the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Candidate-Gene Association Study

Stefanidis, I.; Kreuer, K.; Dardiotis, E.; Arampatzis, S.; Eleftheriadis, T.; Hadjigeorgiou, G. M.; Zintzaras, E.; Mertens, P. R. (2014)

Variants of the interleukin-1 beta gene (IL1B) are implicated in the development of diabetic nephropathy (DN). The present candidate-gene association study was conducted to investigate the association between the IL1B ...

MEIS1 and BTBD9: Genetic association with restless leg syndrome in end stage renal disease

Schormair, B.; Plag, J.; Kaffe, M.; Groß, N.; Czamara, D.; Samtleben, W.; Lichtner, P.; Ströhle, A.; Stefanidis, I.; Vainas, A.; Dardiotis, E.; Sakkas, G. K.; Gieger, C.; Müller-Myhsok, B.; Meitinger, T.; Heemann, U.; Hadjigeorgiou, G. M.; Oexle, K.; Winkelmann, J. (2011)

Background: Restless legs syndrome (RLS) is a sleep related movement disorder that occurs both in an idiopathic form and in symptomatic varieties. RLS is a frequent and distressing comorbidity in end stage renal disease ...

Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease

Michelakakis, H.; Xiromerisiou, G.; Dardiotis, E.; Bozi, M.; Vassilatis, D.; Kountra, P. M.; Patramani, G.; Moraitou, M.; Papadimitriou, D.; Stamboulis, E.; Stefanis, L.; Zintzaras, E.; Hadjigeorgiou, G. M. (2012)

Lysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose-6-phosphateindependent receptor for glucocerebrosidase ...

Perimetric and retinal nerve fiber layer findings in patients with Parkinson's disease

Tsironi, E. E.; Dastiridou, A.; Katsanos, A.; Dardiotis, E.; Veliki, S.; Patramani, G.; Zacharaki, F.; Ralli, S.; Hadjigeorgiou, G. M. (2012)

Background: Visual dysfunction is common in Parkinson's disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings ...

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

Ross, O. A.; Soto-Ortolaza, A. I.; Heckman, M. G.; Aasly, J. O.; Abahuni, N.; Annesi, G.; Bacon, J. A.; Bardien, S.; Bozi, M.; Brice, A.; Brighina, L.; Van Broeckhoven, C.; Carr, J.; Chartier-Harlin, M. C.; Dardiotis, E.; Dickson, D. W.; Diehl, N. N.; Elbaz, A.; Ferrarese, C.; Ferraris, A.; Fiske, B.; Gibson, J. M.; Gibson, R.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Klein, C.; Kruger, R.; Kyratzi, E.; Lesage, S.; Lin, C. H.; Lynch, T.; Maraganore, D. M.; Mellick, G. D.; Mutez, E.; Nilsson, C.; Opala, G.; Park, S. S.; Puschmann, A.; Quattrone, A.; Sharma, M.; Silburn, P. A.; Sohn, Y. H.; Stefanis, L.; Tadic, V.; Theuns, J.; Tomiyama, H.; Uitti, R. J.; Valente, E. M.; van de Loo, S.; Vassilatis, D. K.; Vilarino-Guell, C.; White, L. R.; Wirdefeldt, K.; Wszolek, Z. K.; Wu, R. M.; Farrer, M. J.; Genetic Epidemiology Parkinson's, D. (2011)

Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's ...

Genetic susceptibility to primary intracerebral haemorrhage

Dardiotis, E.; Dardioti, M.; Xiromerisiou, G.; Paterakis, K.; Fountas, K.; Hadjigeorgiou, G. M. (2009)

Primary intracerebral haemorrhage (PICH) originates from the spontaneous rupture of cerebral arteries as a result of chronic degenerative alterations. Although the aetiology of PICH has not been fully elucidated, it may ...

Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma

Tsironi, E. E.; Pefkianaki, M.; Tsezou, A.; Kotoula, M. G.; Dardiotis, E.; Almpanidou, P.; Papathanasiou, A. A.; Rodopoulou, P.; Chatzoulis, D. Z.; Hadjigeorgiou, G. M. (2009)

Purpose: To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients. ...

Paraoxonase 1 (PON1) gene polymorphisins (M55L and Q192R) and osteonecrosis of the femoral head with and without cerebral white matter lesions

Hadjigeorgiou, G. M.; Dardioti, M.; Dardiotis, E.; Aggelakis, K.; Xiromerisiou, G.; Tsimourtou, V.; Noulas, G.; Malizos, K.; Zimbis, A.; Papadimitriou, A.; Karantanas, A. (2005)