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Comparison of simplified score with the revised original score for the diagnosis of autoimmune hepatitis: A new or a complementary diagnostic score?

Gatselis, N. K.; Zachou, K.; Papamichalis, P.; Koukoulis, G. K.; Gabeta, S.; Dalekos, G. N.; Rigopoulou, E. I. (2010)

Background and aims: The International Autoimmune Hepatitis Group developed a simplified score for autoimmune hepatitis. We assessed this "new scoring system" and compared it with the International Autoimmune Hepatitis ...

Autoimmunity and Environment: Am I at risk?

Smyk, D.; Rigopoulou, E. I.; Baum, H.; Burroughs, A. K.; Vergani, D.; Bogdanos, D. P. (2012)

The complex interplay between environmental factors and genetic susceptibility plays an essential role in disease pathogenesis. This is especially true for autoimmunity, where clinical reports, genomic and epidemiological ...

Urinary tract infection as a risk factor for autoimmune liver disease: From bench to bedside

Smyk, D. S.; Bogdanos, D. P.; Kriese, S.; Billinis, C.; Burroughs, A. K.; Rigopoulou, E. I. (2012)

Autoimmune liver diseases include autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis. A variety of environmental and genetic risk factors have been associated with these conditions. ...

Twin studies in autoimmune disease: Genetics, gender and environment

Bogdanos, D. P.; Smyk, D. S.; Rigopoulou, E. I.; Mytilinaiou, M. G.; Heneghan, M. A.; Selmi, C.; Gershwin, M. E. (2012)

Twin studies are powerful tools to discriminate whether a complex disease is due to genetic or environmental factors. High concordance rates among monozygotic (MZ) twins support genetic factors being predominantly involved, ...

Tracing environmental markers of autoimmunity: introducing the infectome

Bogdanos, D. P.; Smyk, D. S.; Invernizzi, P.; Rigopoulou, E. I.; Blank, M.; Sakkas, L.; Pouria, S.; Shoenfeld, Y. (2013)

We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all ...

Infectomics and autoinfectomics: a tool to study infectious-induced autoimmunity

Bogdanos, D. P.; Smyk, D. S.; Rigopoulou, E. I.; Sakkas, L. I.; Shoenfeld, Y. (2015)

The exposome represents all exogenous and endogenous environmental exposures that begin at preconception and carry on throughout life, while the microbiome reflects the microbial component of the exposome. We recently ...

Occult hepatitis B virus infection in patients with autoimmune liver diseases

Georgiadou, S. P.; Zachou, K.; Liaskos, C.; Gabeta, S.; Rigopoulou, E. I.; Dalekos, G. N. (2009)

Occult hepatitis B virus (HBV) infection is characterized by undetectable serum HBV surface antigen (HBsAg) but detectable HBV-DNA in serum or liver. To determine the prevalence and clinical impact of occult HBV in autoimmune ...

p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris

Mavropoulos, A.; Orfanidou, T.; Liaskos, C.; Smyk, D. S.; Billinis, C.; Blank, M.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)

Evidence is beginning to accumulate that p38 mitogen activated protein kinase (p38 MAPK) signaling pathway plays an important role in the regulation of cellular and humoral autoimmune responses. The exact mechanisms and ...

Bone marrow findings in patients with autoimmune liver diseases

Tsikrikoni, A.; Rigopoulou, E. I.; Zachou, K.; Liaskos, C.; Kyriakou, D.; Dalekos, G. N. (2008)

Background and Aims: We have recently reported quantitative and qualitative differences of the bone marrow (BM) hematopoietic progenitor cells in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC). In ...

Infectome: A platform to trace infectious triggers of autoimmunity

Bogdanos, D. P.; Smyk, D. S.; Invernizzi, P.; Rigopoulou, E. I.; Blank, M.; Pouria, S.; Shoenfeld, Y. (2013)

The "exposome" is a term recently used to describe all environmental factors, both exogenous and endogenous, which we are exposed to in a lifetime. It represents an important tool in the study of autoimmunity, complementing ...