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Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration
(2011)
Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be ...
The route of a bullet through the chest and its minimal effect: A report of a "lucky" case sustained gunshot-induced penetrating thoracic injury and review of the literature
(2012)
Thoracic trauma due to blunt or penetrating injury is a major cause of hospitalization worldwide, associated with high mortality rates ranging from 15 to 77%. The majority of thoracic injuries requiring surgical intervention ...
Daptomycin use in patients with osteomyelitis: A preliminary report from the EU-CORESM database
(2013)
Background: Osteomyelitis is a complex and heterogeneous group of infections that require surgical and antimicrobial interventions. Because treatment failure or intolerance is common, new treatment options are needed. ...
Verbal fluency in adults diagnosed with attention-deficit hyperactivity disorder (ADHD) in childhood
(2013)
It has been increasingly believed that attention-deficit hyperactivity disorder (ADHD) is a disorder with lifelong course associated with cognitive difficulties including among others, language production, verbal learning, ...
Radiological and radiotherapeutic approaching of pediatric tumors in head and neck area
(2013)
The most common pediatric malignancies in head and neck area consisted of lymphoma, leukemia, brain tumors, neuroblastoma, Wilms' tumor, sarcomas and primarily rhabdomyosarcoma. This review reports in brief radiological ...
Hereditary hyperferritinemia cataract syndrome as a cause of childhood hyperferritinemia
(2014)
A 2-year-old female was presented with high levels of serum ferritin (890 ng/mL) in a routine blood test. Clinical and laboratory investigations excluded the presence of iron overload and secondary causes of hyperferritinemia. ...
Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach
(2010)
To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). ...
Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: Art of facts or an artifact?
(2013)
Epstein-Barr virus (EBV) can cause frequently asymptomatic (or anicteric) and self-limited hepatitis, while occasionally may result in considerable cholestatic hepatitis. Herein, we describe the case of a previously healthy ...
Systemic sclerosis: From pathogenesis towards targeted immunotherapies
(2012)
Systemic sclerosis (SSc), a chronic disease with widespread collagen deposition, has three pathogenetic facets: immune activation, microvasculopathy and fibroblast activation. Immune activation and microvasculopathy occur ...
Immunoglobulin D myeloma: Clinical features and outcome in the era of novel agents
(2014)
Objectives: Immunoglobulin D (IgD) multiple myeloma is an uncommon variant of the disease probably associated with poorer prognosis. However, data on IgD myeloma patients treated in the novel agent era are lacking. Methods: ...