Μελέτη της διαφοράς διεγερσιμότητας μεταξύ CA1 κυττάρων ραχιαίου και κοιλιακού ιππόκαμπου αρουραίου με τη χρήση προχωρημένων μεθόδων ανάλυσης σήματος

Abstract

The septal and temporal pole of the rat hippocampus appear to differ markedly in their anatomical and neurochemical organization. It is well established both in vivo and in vitro that neurons in temporal slices of the hippocampus , are more excitable t and more prone to epileptiform activity than neurons in septal slices. At the present study intracellular current clamp recordings were made from pyramidal neurons of the CA1 region of both septal and temporal slices of the hippocampus. With the use of parameters in the space of time and frequency and after statistical analysis the following differences between septal and temporal slices were established: They differ on : 1. their waveforms 2. the total power of discharges and thus in the excitability. 3. the λ parameter ( poisson distribution) of the values of interspike intervals and thus in the excitability. ( the duration of the action potentials is larger of the temporal slices). These findings not only come in agreement with previous studies , over the functional differences between septal and temporal hippocampal slices , but they seem to verify the hypothesis that the differentation is due to the intrinsic membrane properties.