Now showing items 1-10 of 10

    • Adverse effects of androgen deprivation therapy in patients with prostate cancer: Focus on muscle and bone health 

      Bargiota A., Oeconomou A., Zachos I., Samarinas M., Pisters L.L., Tzortzis V. (2020)
      Androgen deprivation therapy (ADT) is the most effective systemic treatment for prostate cancer and can be succeeded either surgically or pharmaceutically. Both approaches lead to hypogonadism with a large variety of adverse ...
    • Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus 

      Medina-Gomez C., Kemp J.P., Dimou N.L., Kreiner E., Chesi A., Zemel B.S., Bønnelykke K., Boer C.G., Ahluwalia T.S., Bisgaard H., Evangelou E., Heppe D.H.M., Bonewald L.F., Gorski J.P., Ghanbari M., Demissie S., Duque G., Maurano M.T., Kiel D.P., Hsu Y.-H., Van Der Eerden B.C.J., Ackert-Bicknell C., Reppe S., Gautvik K.M., Raastad T., Karasik D., Van De Peppel J., Jaddoe V.W.V., Uitterlinden A.G., Tobias J.H., Grant S.F.A., Bagos P.G., Evans D.M., Rivadeneira F. (2017)
      Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS ...
    • Bovine Colostrum Supplementation Improves Bone Metabolism in an Osteoporosis-Induced Animal Model 

      Kydonaki EK; Freitas L; Fonseca BM; Reguengo H; Raposo Simón C; Bastos AR; Fernandes EM; Canadas RF; Oliveira JM; Correlo VM; Reis RL; Vliora M; Gkiata P; Koutedakis Y; Ntina G; Pinto R; Carrillo AE; Marques F; Amorim T. (2021)
      Osteoporosis is characterized by bone loss. The present study aims to investigate the effects of bovine colostrum (BC) on bone metabolism using ovariectomized (OVX) and orchidectomized (ORX) rat models. Twenty-seven-week-old ...
    • Bovine colostrum supplementation improves bone metabolism in an osteoporosis-induced animal model 

      Kydonaki E.K., Freitas L., Fonseca B.M., Reguengo H., Simón C.R., Bastos A.R., Fernandes E.M., Canadas R.F., Oliveira J.M., Correlo V.M., Reis R.L., Vliora M., Gkiata P., Koutedakis Y., Ntina G., Pinto R., Carrillo A.E., Marques F., Amorim T. (2021)
      Osteoporosis is characterized by bone loss. The present study aims to investigate the effects of bovine colostrum (BC) on bone metabolism using ovariectomized (OVX) and orchidec-tomized (ORX) rat models. Twenty-seven-week-old ...
    • Development of Convolutional Neural Networks to identify bone metastasis for prostate cancer patients in bone scintigraphy 

      Papandrianos N., Papageorgiou E.I., Anagnostis A. (2020)
      Objective: The main aim of this work is to build a robust Convolutional Neural Network (CNN) algorithm that efficiently and quickly classifies bone scintigraphy images, by determining the presence or absence of prostate ...
    • Flash proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response 

      Velalopoulou A., Karagounis I.V., Cramer G.M., Kim M.M., Skoufos G., Goia D., Hagan S., Verginadis I.I., Shoniyozov K., Chiango J., Cerullo M., Varner K., Yao L., Qin L., Hatzigeorgiou A.G., Minn A.J., Putt M., Lanza M., Assenmacher C.-A., Radaelli E., Huck J., Diffenderfer E., Dong L., Metz J., Koumenis C., Cengel K.A., Maity A., Busch T.M. (2021)
      In studies of electron and proton radiotherapy, ultrahigh dose rates of FLASH radiotherapy appear to produce fewer toxicities than standard dose rates while maintaining local tumor control. FLASHproton radiotherapy (F-PRT) ...
    • Longitudinal Adaptations of Bone Mass, Geometry, and Metabolism in Adolescent Male Athletes: The PRO-BONE Study 

      Vlachopoulos D., Barker A.R., Ubago-Guisado E., Fatouros I.G., Knapp K.M., Williams C.A., Gracia-Marco L. (2017)
      Adolescence is a crucial period for bone development, and exercise can enhance bone acquisition during this period of life. However, it is not known how the different loading sports practiced can affect bone acquisition ...
    • Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology 

      Bjornsdottir G., Stefansdottir L., Thorleifsson G., Sulem P., Norland K., Ferkingstad E., Oddsson A., Zink F., Lund S.H., Nawaz M.S., Bragi Walters G., Skuladottir A.T., Gudjonsson S.A., Einarsson G., Halldorsson G.H., Bjarnadottir V., Sveinbjornsson G., Helgadottir A., Styrkarsdottir U., Gudmundsson L.J., Pedersen O.B., Hansen T.F., Werge T., Banasik K., Troelsen A., Skou S.T., Thørner L.W., Erikstrup C., Nielsen K.R., Mikkelsen S., Andersen S., Brunak S., Burgdorf K., Hjalgrim H., Jemec G., Jennum P., Johansson P.I., Nielsen K.R., Nyegaard M., Bruun M.T., Pedersen O.B., Dinh K.M., Sørensen E., Ostrowski S., Johansson P.I., Gudbjartsson D., Stefánsson H., Þorsteinsdóttir U., Larsen M.A.H., Didriksen M., Sækmose S., Zeggini E., Hatzikotoulas K., Southam L., Gilly A., Barysenka A., van Meurs J.B.J., Boer C.G., Uitterlinden A.G., Styrkársdóttir U., Stefánsdóttir L., Jonsson H., Ingvarsson T., Esko T., Mägi R., Teder-Laving M., Ikegawa S., Terao C., Takuwa H., Meulenbelt I., Coutinho de Almeida R., Kloppenburg M., Tuerlings M., Slagboom P.E., Nelissen R.R.G.H.H., Valdes A.M., Mangino M., Tsezou A., Zengini E., Alexiadis G., Babis G.C., Cheah K.S.E., Wu T.T., Samartzis D., Cheung J.P.Y., Sham P.C., Kraft P., Kang J.H., Hveem K., Zwart J.-A., Luetge A., Skogholt A.H., Johnsen M.B., Thomas L.F., Winsvold B., Gabrielsen M.E., Lee M.T.M., Zhang Y., Lietman S.A., Shivakumar M., Smith G.D., Tobias J.H., Hartley A., Gaunt T.R., Zheng J., Wilkinson J.M., Steinberg J., Morris A.P., Jonsdottir I., Bjornsson A., Olafsson I.H., Ulfarsson E., Blondal J., Vikingsson A., Brunak S., Ostrowski S.R., Ullum H., Thorsteinsdottir U., Stefansson H., Gudbjartsson D.F., Thorgeirsson T.E., Stefansson K., DBDS Genetic Consortium, GO Consortium (2022)
      Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, ...
    • Temperature sensitivity of skeletal ontogeny in Oreochromis mossambicus 

      Campinho, M. A.; Moutou, K. A.; Power, D. M. (2004)
      Sensitivity of skeletal ontogenesis to temperature was assessed in Mozambican tilapia Oreochromis mossambicus and Culture temperature manipulations (22, 27 and 32degrees C) were used to establish if age or length gave the ...
    • Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index 

      Hartley A., Sanderson E., Granell R., Paternoster L., Zheng J., Smith G.D., Southam L., Hatzikotoulas K., Boer C.G., Van Meurs J., Zeggini E., Gregson C.L., Tobias J.H., Stefánsdóttir L., Zhang Y., De Almeida R.C., Wu T.T., Teder-Laving M., Skogholt A.-H., Terao C., Zengini E., Alexiadis G., Barysenka A., Bjornsdottir G., Gabrielsen M.E., Gilly A., Ingvarsson T., Johnsen M.B., Jonsson H., Kloppenburg M.G., Luetge A., Mägi R., Mangino M., Nelissen R.R.G.H.H., Shivakumar M., Steinberg J., Takuwa H., Thomas L., Tuerlings M., Babis G., Cheung J.P.Y., Samartzis D., Lietman S.A., Slagboom P.E., Stefansson K., Uitterlinden A.G., Winsvold B., Zwart J.-A., Sham P.C., Thorleifsson G., Gaunt T.R., Morris A.P., Valdes A.M., Tsezou A., Cheah K.S.E., Ikegawa S., Hveem K., Esko T., Wilkinson J.M., Meulenbelt I., Michael Lee M.T., Styrkársdóttir U. (2022)
      Objectives: Observational analyses suggest that high bone mineral density (BMD) is a risk factor for osteoarthritis (OA); it is unclear whether this represents a causal effect or shared aetiology and whether these relationships ...