Sfoglia per Autore "Sakkas, L. I."
Items 1-20 di 40
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Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment
Sakkas, L. I.; Bogdanos, D. P.; Katsiari, C.; Platsoucas, C. D. (2014)Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein/peptide autoantibodies (ACPAs). Citrulline derives from arginine by peptidyl ... -
Anti-cyclic citrullinated peptide-2 (CCP2) autoantibodies and extra-articular manifestations in Greek patients with rheumatoid arthritis
Alexiou, I.; Germenis, A.; Koutroumpas, A.; Kontogianni, A.; Theodoridou, K.; Sakkas, L. I. (2008)The objective of our study was to establish whether there is an association between rheumatoid arthritis with extra-articular manifestations (exRA) and anti-cyclic citrullinated peptide 2 (anti-CCP2) antibodies in Greeks. ... -
Autoantibodies in patients with systemic sclerosis and cancer: A case control study
Derk, C. T.; Sakkas, L. I.; Rasheed, M.; Artlett, C.; Jimenez, S. A. (2003) -
Autoantibodies in patients with systemic sclerosis and cancer: A case-control study
Derk, C. T.; Sakkas, L. I.; Rasheed, M.; Artlett, C.; Jimenez, S. A. (2003)Objective. To determine the prevalence of specific autoantibodies in a cohort of patients with systemic sclerosis (SSc) and a diagnosis of cancer, and to compare it to that in a group of patients with SSc who were never ... -
Comparison between clinical and ultrasonographic assessment in patients with erosive osteoarthritis of the hands
Koutroumpas, A. C.; Alexiou, I. S.; Vlychou, M.; Sakkas, L. I. (2010)The objective of this study is to assess the reliability of clinical examination in patients with erosive osteoarthritis (EOA). Eighteen patients with EOA underwent clinical examination for joint tenderness, bony swelling, ... -
Conjunctival surface changes in patients with Sjogren's syndrome: A transmission electron microscopy study
Koufakis, D. I.; Karabatsas, C. H.; Sakkas, L. I.; Alvanou, A.; Manthos, A. K.; Chatzoulis, D. Z. (2006)PURPOSE. To demonstrate the ultrastructural appearance of the conjunctival surface epithelium in patients with Sjogren's syndrome (SS) compared with normal subjects. METHODS. Conjunctival tissue specimens from seven normal ... -
Decreased Expression of the CD3ζ Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis
Sakkas, L. I.; Koussidis, G.; Avgerinos, E.; Gaughan, J.; Platsoucas, C. D. (2004)Osteoarthritis (OA) is a heterogeneous disease which rheumatologists consider to be noninflammatory. However, recent studies suggest that, at least in certain patients, OA is an inflammatory disease and that patients often ... -
Demonstration of the human ocular surface glycocalyx by transmission electron microscopy
Koufakis, D. I.; Karabatsas, C. H.; Alvanou, A.; Sakkas, L. I.; Manthos, A. K.; Chatzoulis, D. Z. (2006)The aim of this work was to demonstrate the ultrastructural appearance of the human ocular surface glycocalyx in normal subjects. Conjunctival tissue specimens from 7 normal subjects were obtained by bulbar conjunctival ... -
Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis
Alexiou, I.; Germenis, A.; Ziogas, A.; Theodoridou, K.; Sakkas, L. I. (2007)Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been of diagnostic value in Northern European Caucasian patients with rheumatoid arthritis ( RA). In these populations, anti-CCP antibodies are ... -
Diagnostic value of anticyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis: association with extra-articular manifestations
Alexiou, I.; Germenis, A.; Ziogas, A.; Koutroumbas, A.; Theodoridou, K.; Kontogianni, A.; Sakkas, L. I. (2007) -
Early systemic sclerosis-opportunities for treatment
Sakkas, L. I.; Simopoulou, T.; Katsiari, C.; Bogdanos, D.; Chikanza, I. C. (2015)Systemic sclerosis (SSc) is characterized by microvasculopathy (Raynaud's phenomenon and fibrointimal proliferation), presence of autoantibodies and collagen deposition in skin (scleroderma) and internal organs. ... -
Enthesitis in psoriatic arthritis
Sakkas, L. I.; Alexiou, I.; Simopoulou, T.; Vlychou, M. (2013)Objectives: It is increasingly recognized that enthesitis in patients with psoriatic arthritis (PsA) is of clinical importance. We review data on the detection, assessment, and treatment of enthesitis and its related ... -
Erosive hand osteoarthritis is associated with subclinical atherosclerosis and endothelial dysfunction
Koutroumpas, A.; Giannoukas, A.; Zintzaras, E.; Exarchou, E.; Baliakos, A.; Makaritsis, K.; Sakkas, L. I. (2013)Chronic inflammatory disorders have been associated with accelerated atherosclerosis and increased cardiovascular (CV) risk. Recent evidence suggests that erosive hand osteoarthritis (EOA) has considerable inflammation; ... -
Erosive Osteoarthritis Is Associated with Preclinical Atherosclerosis
Koutroumpas, A.; Giannoukas, A.; Exarchou, A.; Baliakos, A.; Makaritsis, K.; Sakkas, L. I. (2011) -
Flow Cytometric Detection of p38 MAPK Phosphorylation and Intracellular Cytokine Expression in Peripheral Blood Subpopulations from Patients with Autoimmune Rheumatic Diseases
Mavropoulos, A.; Bogdanos, D. P.; Liaskos, C.; Orfanidou, T.; Simopoulou, T.; Zafiriou, E.; Sakkas, L. I.; Rigopoulou, E. I. (2014)Flow cytometric analysis of p38 mitogen-activated protein kinase (p38 MAPK) signaling cascade is optimally achieved by methanol permeabilization protocols. Such protocols suffer from the difficulties to accurately detect ... -
Haematogenous spinal infection: An 8-year experience from a teaching hospital in Greece
Sakkas, L. I.; Davas, E. M.; Kapsalaki, E.; Boulbou, M.; Makaritsis, K.; Loukopoulos, A.; Tsikrikas, T.; Stathakis, N. (2008) -
Helicobacter pylori and autoimmune disease: Cause or bystander
Smyk, D. S.; Koutsoumpas, A. L.; Mytilinaiou, M. G.; Rigopoulou, E. I.; Sakkas, L. I.; Bogdanos, D. P. (2014)Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of ... -
HELICOBACTER PYLORI AS A TRIGGER OF SYSTEMIC SCLEROSIS: IMMUNOLOGICAL ASPECTS
Liaskos, C.; Varna, A.; Simopoulou, T.; Mavropoulos, A.; Mytilinaiou, M.; Rigopoulou, E. I.; Bogdanos, D. P.; Sakkas, L. I. (2014) -
Hematogenous spinal infection in Central Greece
Sakkas, L. I.; Davas, E. M.; Kapsalaki, E.; Boulbou, M.; Makaritsis, K.; Alexiou, I.; Tsikrikas, T.; Stathakis, N. (2009)STUDY DESIGN.: We retrospectively analyzed spinal infection (SpI), in a teaching Hospital, in Central Greece. OBJECTIVE.: To study presentation, etiology, and outcome of SpI in Central Greece. SUMMARY OF BACKGROUND DATA.: ... -
High-resolution ultrasonography and 3.0 T magnetic resonance imaging in erosive and nodal hand osteoarthritis: high frequency of erosions in nodal osteoarthritis
Vlychou, M.; Koutroumpas, A.; Alexiou, I.; Fezoulidis, I.; Sakkas, L. I. (2013)Erosive osteoarthritis (EOA) is defined as hand osteoarthritis (OA) with interphalangeal joint erosions on plain radiographs. We sought to find ultrasound (US) and magnetic resonance imaging (MRI) features that could ...