Auflistung Nach Schlagwort "CRYSTAL-STRUCTURE"
Anzeige der Dokumente 1-20 von 20
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A 40.7 kDa Rpp30/Rpp1 homologue is a protein subunit of Dictyostelium discoideum RNase P holoenzyme
(2007)RNase P is an essential and ubiquitous endonuclease that mediates the maturation of the 5' ends of all precursor tRNA molecules. The holoenzyme from Dictyostelium discoideum possesses RNA and protein subunits essential for ... -
The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors
(2010)Glycogen phosphorylase (GP) is a promising target for the treatment of type 2 diabetes. In the process of structure based drug design for GP, a group of 15 aromatic aldehyde 4-(beta-D-glucopyranosyl) thiosemicarbazones ... -
Building arks for tRNA: Structure and function of the Arc1p family of non-catalytic tRNA-binding proteins
(2010)Following the intricate architecture of the eukaryotic cell, protein synthesis involves formation of many macromolecular assemblies, some of which are composed by tRNA-aminoacylation enzymes. Protein-protein and protein-tRNA ... -
Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro
(2011)Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex ... -
Changes in the level of poly(Phe) synthesis in Escherichia coli ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus can be explained by structural changes in the peptidyltransferase center: a molecular dynamics simulation analysis
(2006)Data from polyphenylalanine [poly(Phe)] synthesis determination in the presence and in the absence of erythromycin have been used in conjunction with Molecular Dynamics Simulation analysis, in order to localize the functional ... -
The contribution of the zinc-finger motif to the function of Thermus thermophilus ribosomal protein S14
(2007)In the crystal structure of the 30S ribosomal subunit from Thermus thermophilus, cysteine 24 of ribosomal protein S14 (TthS14) occupies the first position in a CXXC-X12-CXXC motif that coordinates a zinc ion. The structural ... -
Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4 alpha
(2004)Hepatocyte nuclear factor-4alpha (HNF-4alpha), a member of the nuclear receptor superfamily, is a crucial regulator of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism. Unlike other members ... -
Curcumin analogues as possible anti-proliferative & anti-inflammatory agents
(2011)A series of novel curcumin analogues has been designed, synthesized and tested in vitro/in vivo as potential multi-target agents. Their anti-proliferative and anti-inflammatory activities were studied. Compounds 1b and 2b ... -
hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies
(2012)Human coilin interacting nuclear ATPase protein (hCINAP) directly interacts with coilin, a marker protein of Cajal Bodies (CBs), nuclear organelles involved in the maturation of small nuclear ribonucleoproteins UsnRNPs and ... -
Modulation of catalytic RNA biological activity by small molecule effectors
(2006)Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are ... -
Molecular cloning and biochemical characterization of VIM-12, a novel hybrid VIM-1/VIM-2 metallo-beta-lactamase from a Klebsiella pneumoniae clinical isolate, reveal atypical substrate specificity
(2007)Metallo-beta-lactamases (MBLs) are considered an emerging family of Zn2+-dependent enzymes that significantly contribute to the resistance of many nosocomial pathogens against beta-lactam antimicrobials. Since these ... -
Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes
(2014)Glycogen phosphorylase (GP) (EC 2.4.1.1) is an important therapeutic target for the potential treatment of type 2 diabetes. The search for potent, selective and drug-like GP inhibitors which may eventually lead to hypoglycaemic ... -
NMR Evidence of Charge-Dependent Interaction Between Various PND V3 and CCR5 N-Terminal Peptides
(2009)The third variable (V3) loop is an important region of glycoprotein 120 (gp120) for many biological processes, as it contains the highly conserved GPGR sequence and it represents the binding site for human immunodeficiency ... -
A novel mutation of the hGR gene causing Chrousos syndrome
(2015)Background Natural mutations in the human glucocorticoid receptor (hGR, NR3C1) gene cause Chrousos syndrome, a rare condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids. Objective ... -
Patterns of variability at the major histocompatibility class I and class II loci in populations of the endangered cyprinid Ladigesocypris ghigii
(2011)The patterns of MHC diversity were studied at UAA and DAB1 loci and the two domains involved in the recognition of antigenic peptides (alpha 2 and beta 1, respectively) in eight Ladigesocypris ghigii populations inhabiting ... -
Plant GSTome: structure and functional role in xenome network and plant stress response
(2015)Glutathione transferases (GSTs) represent a major group of detoxification enzymes. All plants possess multiple cytosolic GSTs, each of which displays distinct catalytic as well as non-catalytic binding properties. The ... -
Role of siderophores in cystic fibrosis pathogenesis: Foes or friends?
(2009)Cystic fibrosis (CF) is one of the most common genetic disorders among Caucasians. CF patients are susceptible to chronic lung infections caused by diverse microorganisms, therefore CF should be regarded as a polymicrobial ... -
Siderophores in fluorescent pseudomonads: new tricks from an old dog
(2007)Iron is an essential nutrient for almost all bacteria; however, at neutral pH its bioavailability, is limited. Siderophores are iron-binding compounds of low molecular weight that enable the microorganisms that produce ... -
Structural analysis of the Rhizoctoniasolani agglutinin reveals a domain-swapping dimeric assembly
(2013)Rhizoctoniasolani agglutinin (RSA) is a 15.5-kDa lectin accumulated in the mycelium and sclerotia of the soil born plant pathogenic fungus R.solani. Although it is considered to serve as a storage protein and is implicated ... -
Studies on the Essential Intramolecular Interaction Between the A1 and A2 Domains of von Willebrand Factor
(2013)Haemostasis depends on the balanced participation of von Willebrand factor (vWF), a large multimeric and multidomain glycoprotein with essential role during the initial steps of blood clotting. Mature vWF circulates in ...