Πλοήγηση ανά Θέμα "CLINICAL-TRIALS"
Αποτελέσματα 1-20 από 22
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Analysis of the Quality of Reporting of Randomized Controlled Trials in Acute and Chronic Myeloid Leukemia, and Myelodysplastic Syndromes as Governed by the CONSORT Statement
(2009)PURPOSE: Randomized controlled trials (RCTs) are the best tool to evaluate the effectiveness of clinical interventions. The CONSORT (Consolidated Standards of Reporting Trials) statement is an evidence-based approach to ... -
Are Sample Sizes Clear and Justified in RCTs Published in Dental Journals?
(2014)Sample size calculations are advocated by the CONSORT group to justify sample sizes in randomized controlled trials (RCTs). The aim of this study was primarily to evaluate the reporting of sample size calculations, to ... -
Assessing the Quality of Reporting of Observational Studies in Cancer
(2010)PURPOSE: The vast majority of epidemiological studies in cancer are observational. However, inadequate reporting of the published observational studies (OS) may restrict the generalizability and credibility of study results. ... -
Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials
(2010)A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this ... -
Curcumin analogues as possible anti-proliferative & anti-inflammatory agents
(2011)A series of novel curcumin analogues has been designed, synthesized and tested in vitro/in vivo as potential multi-target agents. Their anti-proliferative and anti-inflammatory activities were studied. Compounds 1b and 2b ... -
Developing the Evidence Base for Cancer Chemoprevention: Use of Meta-Analysis
(2011)Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ... -
Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology
(2009)Objective: Cumulative meta-analysis allows the evaluation of a study's contribution to the combined effect of the preceding research. It accrues evidence, gradually adding studies one at a time and provides updated estimates ... -
Genetic model selection in genome-wide association studies: robust methods and the use of meta-analysis
(2013)In genetic association studies (GAS) as well as in genome-wide association studies (GWAS), the mode of inheritance (dominant, additive and recessive) is usually not known a priori. Assuming an incorrect mode of inheritance ... -
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility
(2008)We have performed a meta-analysis combining data for more than 11 000 individuals. It provides compelling evidence for a positive association between a functional single-nucleotide polymorphism (SNP) in the 5'-UTR of GDF5 ... -
A method for meta-analysis of case-control genetic association studies using logistic regression
(2007)We propose here a simple and robust approach for meta-analysis of molecular association studies. Making use of the binary structure of the data, and by treating the genotypes as independent variables in a logistic regression, ... -
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis
(2007)Investigations into the association between diabetic nephropathy (DN) and MTHFR C677T gene polymorphism in several case-control studies has yielded contradictory results. To shed light on these inconclusive findings, a ... -
Network Analysis of Randomized Controlled Trials in Multiple Sclerosis
(2012)Background: The optimal treatment of multiple sclerosis (MS) is not yet well-defined. Objective: To estimate the relative effectiveness of treatments in MS, we performed a network of multiple-treatments meta-analysis of ... -
Polymorphisms of the CD24 Gene Are Associated with Risk of Multiple Sclerosis: A Meta-Analysis
(2015)CD24 is a cell-surface protein mainly expressed in cells of the immune and central nervous system (CNS), cells that play a critical role in the development of multiple sclerosis (MS). In the current study, we investigated ... -
Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: A Mendelian randomization meta-analysis
(2010)Polycystic ovary syndrome (PCOS) is a heterogeneous condition with unknown aetiology which is considered to be the most common endocrine disorder in women of reproductive age. In this work we investigated the association ... -
A prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies
(2014)Invasive candidiasis is a life-threatening infection in patients with haematological malignancies. The objective of our study was to determine the incidence, microbiological characteristics and clinical outcome of candidaemia ... -
Publication bias in reproductive medicine: from the European Society of Human Reproduction and Embryology annual meeting to publication
(2011)Background: Treatment decisions should ideally be based on well-designed randomized controlled trials (RCTs). Here we determine the rate of full publication of RCTs presented at annual meetings of the European Society of ... -
Radiotherapy for Hodgkin's lymphoma: too hard to die?
(2012)The treatment of Hodgkin's lymphoma (HL) is associated with significant toxicity. The objective of high quality management is to keep the concept of combined modality, while trying to decrease the radiation dose, to diminish ... -
Randomized Trials of Dopamine Agonists in Restless Legs Syndrome: A Systematic Review, Quality Assessment, and Meta-Analysis
(2010)Background: The use of dopamine agonists (DAs) for the treatment of restless legs syndrome (RLS) has been assessed in numerous randomized clinical trials (RCTs). Objectives: The aims of this study were to assess the reporting ... -
The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis
(2005)The association between retincipathy in type 2 diabetes [diabetic retinopathy (DR)] and the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been investigated in several case-control studies. ... -
Sleep-disordered breathing and blood pressure in children - A meta-analysis
(2007)Objectives: To estimate the risk of elevated blood pressure (BP) in children with obstructive sleep-disordered breathing (SDB) and to explore heterogeneity among published studies. Data Source: PubMed database. Study ...