Πλοήγηση ανά Θέμα "ANTAGONISTS"
Αποτελέσματα 1-4 από 4
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Efficient soluble expression of active recombinant human cyclin A2 mediated by E. coli molecular chaperones
(2015)Bacterial expression of human proteins continues to present a critical challenge in protein crystallography and drug design. While human cyclin A constructs have been extensively characterized in complex with cyclin dependent ... -
Iterative Conversion of Cyclin Binding Groove Peptides into Drug like CDK Inhibitors with Antitumor Activity
(2015)The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective inhibition of kinase activity through a non-ATP competitive ... -
Optimization of Non-ATP Competitive CDK/Cyclin Groove Inhibitors through REPLACE-Mediated Fragment Assembly
(2013)A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational ... -
Uric acid induces caspase-1 activation, IL-1 beta secretion and P2X7 receptor dependent proliferation in primary human lymphocytes
(2013)Background: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1 beta (IL-1 beta). Purinergic receptor ...