• Adrenal, thyroid and gonadal axes are affected at high altitude 

      Wolff M.V., Nakas C.T., Tobler M., Merz T.M., Hilty M.P., Veldhuis J.D., Huber A.R., Hefti J.P. (2018)
      Humans cannot live at very high altitude for reasons, which are not completely understood. Since these reasons are not restricted to cardiorespiratory changes alone, changes in the endocrine system might also be involved. ...
    • Delayed diagnosis of Prader-Willi syndrome in a 24 year-old patient 

      Kyriazis, I. A.; Mendrinos, D.; Saridi, M.; Rekliti, M.; Toska, A.; Wozniak, G.; Roupa, Z. (2010)
      Background: Prader-Willi syndrome (PWS) is the most common known genetic cause of life-threatening obesity in children. The purpose of the study was to present the case of a delayed diagnosis of PWS in a 24-year-old male ...
    • Dexamethasone reduces acrosin activity of ram spermatozoa 

      Tsantarliotou, M. P.; Taitzoglou, I. A.; Goulas, P.; Kokolis, N. A. (2002)
      The aim of this study was to investigate the effect of dexamethasone on acrosin activity of spermatozoa in Chios rams during autumn (breeding season for sheep in Greece), in correlation with possible changes in blood ...
    • The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome 

      Dragamestianos C., Messini C.I., Antonakis P.T., Zacharouli K., Kostopoulou E., Makrigiannakis A., Georgoulias P., Anifandis G., Dafopoulos K., Garas A., Daponte A., Messinis I.E. (2019)
      Objectives: To investigate the effect of metformin on endometrial receptivity in women with polycystic ovary syndrome (PCOS). Methods: Twenty volunteer women with polycystic ovaries and oligomenorrhea were prospectively ...
    • Efforts to create an artificial testis: Culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment 

      Soffikitis, N.; Pappas, E.; Kawatani, A.; Baltogiannis, D.; Loutradis, D.; Kanakas, N.; Giannakis, D.; Dimitriadis, F.; Tsoukanelis, K.; Georgiou, I.; Makrydimas, G.; Mio, Y.; Tarlatzis, V.; Melekos, M.; Miyagawa, I. (2005)
      Induction of meiotic and post-meiotic alterations of male germ cells in vitro has been the target of several research efforts since 1960. However, to date, the establishment of an ideal culture system in which spermatogonial ...
    • Hormonal responses to three training protocols in rowing 

      Kokalas, N.; Tsalis, G.; Tsigilis, N.; Mougios, V. (2004)
      The aim of this study was to examine the acute responses of serum growth hormone, testosterone, and cortisol to three training protocols in rowing. Six young rowers, members of the national team, carried out three frequently ...
    • In early pubertal boys, testosterone and LH are associated with improved anti-oxidation during an aerobic exercise bout 

      Paltoglou G., Avloniti A., Chatzinikolaou A., Stefanaki C., Papagianni M., Papassotiriou I., Fatouros I.G., Chrousos G.P., Kanaka-Gantenbein C., Mastorakos G. (2019)
      Purpose: To investigate the association of the hypothalamic-pituitary-testicular (HPT) axis with pro- and anti- oxidation, in relation to puberty and obesity in boys, before and after an aerobic exercise bout. Methods: ...
    • Leptin and exercise: An update 

      Cicchella A., Carluccio M., Scoditti E., Kaltsatou A., Massaro M. (2020)
      Leptin is a multifunctional hormone (adipocytokine) involves in several biological processes. From brain metabolism, to signalling, in sexual development, inflammation, fat metabolism, as an ergogenic aid for sport and in ...
    • Non-genomic effect of testosterone on airway smooth muscle 

      Kouloumenta, V.; Hatziefthimiou, A.; Paraskeva, E.; Gourgoulianis, K.; Molyvdas, P. A. (2006)
      Background and purpose: Recent studies on blood vessels have provided evidence that testosterone may exert direct effects on smooth muscle. However, an acute effect on airway reactivity has not been shown yet. The aim of ...
    • Physical activity may be a potent regulator of bone turnover biomarkers in healthy girls during preadolescence 

      Kambas A., Leontsini D., Avloniti A., Chatzinikolaou A., Stampoulis T., Makris K., Draganidis D., Jamurtas A.Z., Tournis S., Fatouros I.G. (2017)
      This study investigated the effects of different levels of habitual physical activity (PA) assessed by pedometry on bone turnover markers of preadolescent girls according to a cross-sectional experimental design. Sixty ...
    • The rat adequately reflects human responses to exercise in blood biochemical profile: A comparative study 

      Goutianos G., Tzioura A., Kyparos A., Paschalis V., Margaritelis N.V., Veskoukis A.S., Zafeiridis A., Dipla K., Nikolaidis M.G., Vrabas I.S. (2015)
      Animal models are widely used in biology and the findings of animal research are traditionally projected to humans. However, recent publications have raised concerns with regard to what extent animals and humans respond ...
    • Regulation of aromatase expression by hormones, drugs pesticides and environmental pollutants in canine mammary CMT-U27 cells 

      Mavridis, S. K.; Pappas, I. S. (2010)
      Aromatase, the enzyme that coverts testosterone to 17β-estradiol, has attracted attention lately because of its involvement in some forms of breast cancer in women. Studies are now undergoing on a variety of species to ...
    • Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review) 

      Krasanakis T., Nikolouzakis T.K., Sgantzos M., Mariolis-Sapsakos T., Souglakos J., Spandidos D.A., Tsitsimpikou C., Tsatsakis A., Tsiaoussis J. (2019)
      Colorectal cancer (CRC) is one of the four leading causes of cancer-related mortality worldwide. Even though over the past few decades the global scientific community has made tremendous efforts to understand this entity, ...
    • The role of hypofractionated radiotherapy for the definitive treatment of localized prostate cancer: Early results of a randomized trial 

      Alexidis P., Dragoumis D., Karatzoglou S., Drevelegas K., Tzitzikas I., Hatzimouratidis K., Chrisogonidis I., Giannakidis D., Koulouris C., Katsaounis A., Michalopoulos N., Huang H., Li Q., Aidoini Z., Fyntanidou V., Amaniti A., Hohenforst-Schmidt W., Maragouli E., Petanidis S., Zarogoulidis P., Sapalidis K., Kosmidis C., Romanidis K., Oinkonomou P., Vagionas A., Nikolaos-Katsios I., Ioannidis A., Boniou K., Kesisoglou I. (2019)
      Background: Prostate cancer is considered to have a special biology which could affect the radiation therapy result based on the selected fractionation scheme. We present the preliminary results of a randomized trial ...
    • Simulating real-life exposures to uncover possible risks to human health: A proposed consensus for a novel methodological approach 

      Tsatsakis A.M., Kouretas D., Tzatzarakis M.N., Stivaktakis P., Tsarouhas K., Golokhvast K.S., Rakitskii V.N., Tutelyan V.A., Hernandez A.F., Rezaee R., Chung G., Fenga C., Engin A.B., Neagu M., Arsene A.L., Docea A.O., Gofita E., Calina D., Taitzoglou I., Liesivuori J., Hayes A.W., Gutnikov S., Tsitsimpikou C. (2017)
      In real life, consumers are exposed to complex mixtures of chemicals via food, water and commercial products consumption. Since risk assessment usually focuses on individual compounds, the current regulatory approach doesn't ...
    • Single-nucleotide polymorphism rs 175080 in the MLH3 gene and its relation to male infertility 

      Markandona O., Dafopoulos K., Anifandis G., Messini C.I., Dimitraki M., Tsezou A., Georgoulias P., Messinis I.E. (2015)
      Purpose: MLH3, a MutL homolog protein in mammals playing a role in DNA mismatch repair, is associated with spermatogenesis and male infertility. The purpose of the present study was to investigate the association of the ...
    • Testosterone and dihydrotestosterone modulate the redox homeostasis of endothelium 

      Koukoulis G.N., Filiponi M., Gougoura S., Befani C., Liakos P., Bargiota Α. (2022)
      The predominance of cardiovascular diseases among men compared to premenopausal women has been attributed to testosterone, which is implicated in vascular remodeling. Molecular mechanisms underlying its role have not been ...
    • Transdermal testosterone pretreatment in poor responders undergoing ICSI: A randomized clinical trial 

      Bosdou J.K., Venetis C.A., Dafopoulos K., Zepiridis L., Chatzimeletiou K., Anifandis G., Mitsoli A., Makedos A., Messinis I.E., Tarlatzis B.C., Kolibianakis E.M. (2016)
      STUDY QUESTION: Does pretreatment with transdermal testosterone increase the number of cumulus-oocyte complexes (COCs) retrieved by more than 1.5 in poor responders undergoing intracytoplasmic sperm injection (ICSI), using ...